2015
DOI: 10.1155/2015/970619
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Synthesis of Thermal Polymerizable Alginate‐GMA Hydrogel for Cell Encapsulation

Abstract: Alginate is a negative ionic polysaccharide that is found abundantly in nature. Calcium is usually used as a cross-linker for alginate. However, calcium cross-linked alginate is used only forin vitroculture. In the present work, alginate was modified with glycidyl methacrylate (GMA) to produce a thermal polymerizable alginate-GMA (AA-GMA) macromonomer. The molecular structure and methacrylation (%DM) of the macromonomer were determined by1H NMR. After mixing with the correct amount of initiator, the AA-GMA aqu… Show more

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Cited by 26 publications
(32 citation statements)
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“…2.00 ppm), which vary in location depending on the resulting chemical environment. In good agreement with previous publications, the signals corresponding to the vinyl hydrogens of the Mx groups appeared as two well-defined singlets at 5.79 and 6.21, 5.76 and 6.16, and 5.27 and 5.58 ppm for ALGM1 [23], ALGM2 [22], and ALGM3 [35], respectively. Meanwhile, the signal ascribed to the methyl hydrogens of each Mx appeared as a well-defined singlet at 1.97, 1.95, and 1.80 ppm for the macromers discussed in the very same order, respectively.…”
Section: Synthesis Of Macromers and 1 H-nmr Characterizationsupporting
confidence: 92%
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“…2.00 ppm), which vary in location depending on the resulting chemical environment. In good agreement with previous publications, the signals corresponding to the vinyl hydrogens of the Mx groups appeared as two well-defined singlets at 5.79 and 6.21, 5.76 and 6.16, and 5.27 and 5.58 ppm for ALGM1 [23], ALGM2 [22], and ALGM3 [35], respectively. Meanwhile, the signal ascribed to the methyl hydrogens of each Mx appeared as a well-defined singlet at 1.97, 1.95, and 1.80 ppm for the macromers discussed in the very same order, respectively.…”
Section: Synthesis Of Macromers and 1 H-nmr Characterizationsupporting
confidence: 92%
“…ALGM1 was synthesized as reported elsewhere [23], although with some optimizations. Briefly, ALG was dissolved into 100 mL of Milli-Q water to produce a 2% (w/v) solution.…”
Section: Synthesis Of Alginate-glycidyl Methacrylate (Algm1)mentioning
confidence: 99%
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“…Nevertheless, very low number of cells might weaken the alginic-calcium bond that leads to reduced rigidity of the alginate hydrogel beads, similar to as reported previously [12]. Thus, the starting cell number of 1 × 10 6 cells/ml was chosen for this study, which was in line with previous work that used a million number of cells/ml as their seeding density [16].…”
Section: Discussionmentioning
confidence: 61%
“…However, it was postulated that the trans-esterification reaction would be mainly favored because the formed glycidol is a good leaving group (Van Dijk-Wolthuis et al, 1995). Recently, GMA was used to modify alginate for producing thermal in-situ polymerizable hydrogels at physiological temperature for cell encapsulation (Wang et al, 2015). The main goal behind this work is to graft GMA onto PVA and optimize the grafting reaction through the grafting conditions such as, GMA concentration and reaction temperature/time.…”
Section: Introductionmentioning
confidence: 99%