Synthesis of the Ligand (Z)-2-(3-Methoxyphenylamino)-4-Oxo-4-Phenylbut-2-Enoic Acid and Its Antifungal Activity Against the Wood Stain Fungi Mucor Plumbeus

Abstract

The ligand (z)-2-(3-methoxyphenylamino)-4-oxo-4-phenylbut-2-enoic acid and its Ni (II) complex were synthesized and their antifungal activity against the fungi wood stain Mucor plumbeus was evaluated. The ligand displayed fungostatic activity while the Ni (II) complex exhibited antifungal activity with a MIC of 50 μg/mL, moreover the copper complex did not showed biocide activity.