Synthesis of the first mixed-donor spiro-linked macrocyclic tetralactams

Abstract

A synthesis of spiro-linked macrocyclic tetraamides 1 and 2 was accomplished by the reaction of pentaerythrityl tetrabromide 13 with two moles of the appropriate dipotassium salts 5a and 5b in refluxing DMF. Treatment of 1 and 2 with Lawesson`s reagent in refluxing toluene afforded the novel spiro-linked macrocyclic tetrathiotetraamides 14 and 15, respectively.