Abstract:The fully substituted C17–C30 bis-tetrahydrofuran fragment of the proposed structure of iriomoteolide-13a has been assembled via asymmetric dihydroxylation–SN2 cyclization of 19-mesyloxy-21-ene-26-yne and PdCl2-catalyzed syn-oxypalladation of 26-ene-17,21,23,28-tetraol as the key steps. The syn-oxypalladation process gave an 89:11 diastereoselectivity and tolerated the free poly-hydroxy groups in the highly functionalized substrate.
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