Synthesis of tetrazole derivatives through conversion of amide and thioamide functionalities

The copper‐catalyzed oxidative azide‐olefin cycloaddition (OAOC) reaction of differently substituted α,β‐unsaturated carbonyls with azides provided an efficient method for preparing biologically active 1,4,5‐trisubstituted 1,2,3‐triazoles. In this study, the cycloaddition reaction was found to be a simple and powerful method for constructing diverse mono‐ and bis‐(1,4,5‐trisubstituted 1,2,3‐triazole) functionalized heterocyclic compounds in moderate to high yields with great regioselectivity. The XRD‐analysis data of one of the bis‐triazole derivatives supported the regioselectivity as well as the conformity of the method in the construction of the triazole nucleus. The preliminary antifungal profile against C. albicans was observed with cinnamaldehyde‐based triazole derivatives demonstrating promising results.

show abstract

Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazole Derivatives from α,β‐Unsaturated Carbonyls

Verma

Bera

Gonnade³

et al. 2022

Eur J Org Chem

Self Cite

View full text Add to dashboard Cite

show abstract

Construction of Tetrazole Derivatives via Sequential Ugi‐N₃/Pd‐Catalyzed Isocyanide Insertion Reactions

Fan

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

Herein, a straightforward method for the construction of tetrazole derivatives has been achieved through Pd-catalyzed isocyanide insertion reactions, which is a good extension for the response of multi-molecule isocyanides. The Ugi-N 3 reaction was introduced to the transformation to enrich the diversity of skeleton structures. The commercially available starting materials and moderate to good yields make this method a valuable tool for generating N-containing heterocyclic compounds.

show abstract

Synthesis of 6,7-dihydro-5H-benzo[c]-1,2,4-triazolo[3,4-a]azepines and 6,7-dihydro-5H-benzo[c]tetrazolo[5,1-a]azepines

Глушков

Mosheva

Zaitsev

et al. 2022

Chem Heterocycl Comp

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synthesis of tetrazole derivatives through conversion of amide and thioamide functionalities

Cited by 6 publications

References 39 publications

Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazole Derivatives from α,β‐Unsaturated Carbonyls

Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazole Derivatives from α,β‐Unsaturated Carbonyls

Construction of Tetrazole Derivatives via Sequential Ugi‐N₃/Pd‐Catalyzed Isocyanide Insertion Reactions

Synthesis of 6,7-dihydro-5H-benzo[c]-1,2,4-triazolo[3,4-a]azepines and 6,7-dihydro-5H-benzo[c]tetrazolo[5,1-a]azepines

Contact Info

Product

Resources

About

Synthesis of tetrazole derivatives through conversion of amide and thioamide functionalities

Cited by 6 publications

References 39 publications

Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazole Derivatives from α,β‐Unsaturated Carbonyls

Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazole Derivatives from α,β‐Unsaturated Carbonyls

Construction of Tetrazole Derivatives via Sequential Ugi‐N3/Pd‐Catalyzed Isocyanide Insertion Reactions

Synthesis of 6,7-dihydro-5H-benzo[c]-1,2,4-triazolo[3,4-a]azepines and 6,7-dihydro-5H-benzo[c]tetrazolo[5,1-a]azepines

Contact Info

Product

Resources

About

Construction of Tetrazole Derivatives via Sequential Ugi‐N₃/Pd‐Catalyzed Isocyanide Insertion Reactions