Synthesis of Tetrakis-Tetrazole via a Repetitive MCR

Abstract

The synthesis of novel and complex molecules tetrakis-tetrazole were synthesized via a Ugi-azide repetitive reaction from easily accessible starting materials in good yields. The use of orthogonal bifunctional reagents in isocyanide based multicomponent reactions (IMCR) allowed the synthesis of structurally complex molecules in one pot manner. The molecules herein synthesized could have applications, such as chelating agents and organocatalysts.