Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

Ahn, Chan Mug; Park, Byong‐Gon; Woo, Ho Bum; Ham, Jungyeob; Shin, Woon‐Seob; Lee, Seokjoon

doi:10.1016/j.bmcl.2009.01.019

Cited by 18 publications

(9 citation statements)

References 17 publications

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“…Curcumin consumed orally is metabolized primarily in the intestine, resulting in the production of biologically active metabolites. An increase in these metabolites may be responsible for improvements in health and arterial function observed in the current study (Ahn and others, 2009; Nakmareong and others, 2011b). Moreover, it is important to note that curcumin is metabolized much more extensively in human compared with rodent intestinal tissues (Ireson and others, 2002; Sharma and others, 2005).…”

Section: Discussionmentioning

confidence: 63%

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

Fleenor

Sindler

Marvi

et al. 2013

Experimental Gerontology

124

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We tested the hypothesis that curcumin supplementation would reverse arterial dysfunction and vascular oxidative stress with aging. Young (Y, 4–6 mo) and old (O, 26–28 mo) male C57BL6/N mice were given normal or curcumin supplemented (0.2%) chow for 4 weeks (n = 5–10/group/measure). Large elastic artery stiffness, assessed by aortic pulse wave velocity (aPWV), was greater in O (448 ± 15 vs. 349 ± 15 cm/s) and associated with greater collagen I and advanced glycation end-products and less elastin (all P < 0.05). In O, curcumin restored aPWV (386 ± 15 cm/s), collagen I and AGEs to levels not different vs. Y. Ex vivo carotid artery acetylcholine (ACh)-induced endothelial-dependent dilation (EDD, 79 ± 3 vs. 94 ± 2%), nitric oxide (NO) bioavailability and protein expression of endothelial NO synthase (eNOS) were lower in O (all P < 0.05). In O, curcumin restored NO-mediated EDD (92 ± 2%) to levels of Y. Acute ex vivo administration of the superoxide dismutase (SOD) mimetic TEMPOL normalized EDD in O control mice (93 ± 3%), but had no effect in Y control or O curcumin treated animals. O had greater arterial nitrotyrosine abundance, superoxide production and NADPH oxidase p67 subunit expression, and lower manganese SOD (all P < 0.05), all of which were reversed with curcumin. Curcumin had no effects on Y. Curcumin supplementation ameliorates age-associated large elastic artery stiffening, NO-mediated vascular endothelial dysfunction, oxidative stress and increases in collagen and AGEs in mice. Curcumin may be a novel therapy for treating arterial aging in humans.

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Section: Discussionmentioning

confidence: 63%

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

Fleenor

Sindler

Marvi

et al. 2013

Experimental Gerontology

124

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“…Alternatively, blood vessel occlusion by red blood cell plugging and thrombosis formation is found in the ischemic tissue surrounding a burn ( Moritz, 1947 ; Regas and Ehrlich, 1992 ; Vo, Papword, Delaney, 1998 ) and may be why tissue necrosis extends from the primary burn site. As curcumin is vasoactive in large arteries from some tissues and species ( Ahn, Park, Woo et al, 2009 ; Gilani, Shah, Ghayur et al, 2005 ; Sasaki, Gogo, Tohda et al, 2003 ; Xu, Long, Dai and Liu, 2007 ), we wondered whether some of the beneficial effect of curcumin was related to a vasomotor effect on the microvasculature.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have shown that curcumin is vasoactive; no previous report has investigated curcumin's action on the microcirculation. Studies in macrovessels typically tested micromolar levels of various curcuminoid preparations, and found a decrease in tension development for artery rings from porcine coronary arteries, rat aorta, and rabbit basilar arteries ( Ahn, Park, Woo et al, 2009 ; Sasaki, Gogo, Tohda et al, 2003 ; Xu, Long, Dai and Liu, 2007 ), but not rabbit aorta ( Gilani, Shah, Ghayur et al, 2005 ); decreased tension is interpreted as dilation. From the limited literature, the mechanism by which curcumin decreases tension appears to be at most half NO-mediated (half attributed to β-Ad, Xu, Long, Dai and Liu, 2007 ), yet the vasoactivity appears to widely differ by tissue and species, or perhaps by curcuminoid preparation or extraction procedure.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Mediates Both Dilation and Constriction of Peripheral Arterioles via Adrenergic Receptors

Dewar

Clark

Singer

et al. 2011

Journal of Investigative Dermatology

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Curcumin has wound healing attributes mediated through a plethora of biological activities that in general are not ascribed to specific receptors. Recently we have demonstrated that i.v. curcumin limits burn injury progression in a rat model. Since decreased microvascular perfusion is a central element of burn injury progression, we hypothesized that curcumin may induce vasodilation in peripheral arterioles, to improve perfusion. Using mucosal microcirculation as an in situ assay, cheek pouch tissue was exteriorized in anesthetized (phentobarbital 70 mg/kg i.p.) male hamsters (N=60) to observe the terminal feed arterioles (~8μm diameter) and the immediately upstream arcade arterioles (~20μm). Curcumin (10−12 – 10−4mol/L) was applied dose-wise (micropipette, 60 seconds). Subnanomolar curcumin dilated whereas micromolar doses constricted the arterioles. For the terminal arteriole: vasodilation logEC50 −10.3±0.2, peak dilation +39±1%; vasconstriction logEC50 −8.0±0.4, peak constriction −14±2%. Simultaneous atropine (muscarinic antagonist) or PD142893 (endothelin antagonist) had no effect. Propranolol (β-Ad antagonist) enhanced constriction by removing the vasodilation response to curcumin. Phentolamine (α-Ad antagonist) enhanced dilation to curcumin by removing the vasoconstriction response. Thus, the curcumin vasomotor activity on microcirculation was α-Ad and β-Ad receptor-dependent and its net vasoactive effect was concentration and time dependent.

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“…This clearly demonstrates that vasorelaxation to nano-curcumin is mediated by endothelium-dependent and independent component in MUA of NP and P Ch. Curcumin -induced vasorelaxation has been reported in rat aorta 15 , porcine coronary arteries 16 , rabbit basilar arteries 17 , rat mesenteric arteries 18 , goat ruminal artery 19, and uterine artery 20 .…”

Section: Cumulative Addition Of Graded Concentration Ofmentioning

confidence: 99%

Untitled

2020

IJPSR

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The present study is designed to investigate vasorelaxation mechanisms of Nanocurcumin in the middle uterine artery (MUA) of both non-pregnant (NP) and pregnant (P) Capra hircus (Ch). Methods: MUA rings were mounted in an automatic organ bath and the contractile response was recorded isometrically by highly sensitive force transducer connected to a power lab data acquisition system. Nanocurcumin (1 pM-100 µM) vasorelaxation response (NCVR) was elicited in PEprecontracted rings either in the absence or presence of different blockers. Results: The maximal vasorelaxation (R max) to Nanocurcumin in phenylephrine-precontracted endothelium intact MUA rings of NP (40.36 ± 2.38%) and of P (44.09 ± 3.41%) was reduced to 22.93 ± 0.80% and 25.37 ± 2.2% in endothelium-denuded MUA rings of NP and P Ch. L-NAME, Indomethacin and L-NAME + Indomethacin inhibited NCVR by significantly decreasing the R max to 17.65%, 28.42%, 17.95% in NP and to 27.34%, 39.06%, 24.50% in P Ch. The ODQ and carbenoxolone/18β Glycyrrhetinic acid did not inhibit the R max of NCVR. Conclusion: Nanocurcumin potentially dilates the MUA of both NP and PCh. The endothelial L-NAME sensitive eNOS is activated by Nanocurcumin and it has the potential to increase blood flow to the uterus and fetus. Additionally, it could also be useful in the effective treatment of hypertensive disorders such as pre-eclampsia. INTRODUCTION: Hypertension is the most common health disorder of pregnancy and is reported to complicate up to 10% of pregnancies and is associated with increased maternal and neonatal morbidity and mortality 1. NO maintains vascular tone by relaxing vascular smooth muscle cells 2 .

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Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

Cited by 18 publications

References 17 publications

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

Curcumin ameliorates arterial dysfunction and oxidative stress with aging

Curcumin Mediates Both Dilation and Constriction of Peripheral Arterioles via Adrenergic Receptors

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