Synthesis of substituted coumarins catalyzed by sawdust-SO3H. An efficient and environmentally benign solid acid catalyst under solvent-free conditions

Tahanpesar, Elham; Sarami, L.

doi:10.1134/s1070363215090182

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…The biodegradable and recyclable solid sawdust–SO 3 H catalyst afforded coumarins via the Pechmann reaction at 110 °C, in high yields, within a short time (<1 h), no solvent, and easy work-up procedure [ 75 ].…”

Section: Synthetic Strategies For the Preparation Of Coumarinsmentioning

confidence: 99%

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

et al. 2018

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Many naturally occurring substances, traditionally used in popular medicines around the world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal chemists, because of its peculiar physicochemical features, and the versatile and easy synthetic transformation into a large variety of functionalized coumarins. As a consequence, a huge number of coumarin derivatives have been designed, synthesized, and tested to address many pharmacological targets in a selective way, e.g., selective enzyme inhibitors, and more recently, a number of selected targets (multitarget ligands) involved in multifactorial diseases, such as Alzheimer’s and Parkinson’s diseases. In this review an overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations. The many existing and recent reviews in the field prompted us to make some drastic selections, and therefore, the review is focused on monoamine oxidase, cholinesterase, and aromatase inhibitors, and on multitarget coumarins acting on selected targets of neurodegenerative diseases.

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Section: Synthetic Strategies For the Preparation Of Coumarinsmentioning

confidence: 99%

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

et al. 2018

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“…Tahanpesar and Sarami reported the synthesis of substituted coumarins (7) via one-pot Pechmann condensation reaction between substituted phenols (5) and β-ketoesters (6) in presence of sulfonated sawdust (SD-SO 3 H) as solid acid catalyst under solvent-free conditions ( Scheme 32 ). 91 Further, they observed the catalytic efficiency of SD-SO 3 H on the yield of product and results were presented in Table 31 . They also observed the effects of different solvents viz.…”

Section: Synthesis Of Substituted Coumarins Using Solid Acid Catalystsmentioning

confidence: 99%