Synthesis of Substituted Arylidene Hydrazinyl Trifluoromethyl Thiazole Derivatives and their Antibacterial Studies using different Genes Expression
Ali Adnan Abed,
Mohammed Adnan Abid,
Ahmed Turki
et al.
Abstract:Cyclization of substituted thiosemicarbazones with 3‐bromo‐1,1,1‐trifluoroacetone affords new 2‐(arylidenehydrazinyl)‐4‐trifluoromethylthiazoles (3 a–m, 13 examples, 71–89 %). These compounds were synthesized in two steps and characterized using 1H‐, 13C‐NMR, FTIR spectroscopy, and HRMS. All of these compounds show potent activity against both Escherichia coli (E. coli) and Klebsiella pneumonia (K. pneumonia) bacterial strains. The compounds 2‐(2‐(1‐(4‐fluorophenyl)ethylidene)hydrazinyl)‐4(trifluoromethyl)thia… Show more
This manuscript discloses the visible-light photocatalytic radical addition into olefins using bromotrifluoroacetone as the trifluoroacetonyl radical precursor.
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