2013
DOI: 10.1002/jbm.a.34744
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Synthesis of strong polycations with improved biological properties

Abstract: Poly(allylamine hydrochloride) (PAH) has found many applications both in biotechnology and biomedical fields. However, its high toxicity toward various mammalian cells significantly limits its effective usage. This study focuses on improving the biological properties of PAH by its modification to strong polyelectrolytes. The strong polycations were prepared by the direct quaternization of PAH amino groups or by the attachment of glycidyltrimethylammonium chloride to these groups. The biological properties, suc… Show more

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Cited by 28 publications
(42 citation statements)
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“…s4). These results are in line with previously reported findings, that the toxicity of PAH can be reduced by transforming its primary amino groups into the quaternary ammonium ones [20]. Moreover, the attachment of hydrophobic hexyl groups (PAHex) resulted in a further increase of the cell viability.…”
Section: Cytotoxicity Of the Polyelectrolytes In Solutionsupporting
confidence: 93%
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“…s4). These results are in line with previously reported findings, that the toxicity of PAH can be reduced by transforming its primary amino groups into the quaternary ammonium ones [20]. Moreover, the attachment of hydrophobic hexyl groups (PAHex) resulted in a further increase of the cell viability.…”
Section: Cytotoxicity Of the Polyelectrolytes In Solutionsupporting
confidence: 93%
“…It is the expected result, since this polymer is well known for its high cytotoxicity against various cell lines, e.g. human fibroblasts [20], human cervix epithelial carcinoma HeLa, human kidney cells 293T, and human hepatoblastoma HepG2 [22].…”
Section: Cytotoxicity Of the Polyelectrolytes In Solutionmentioning
confidence: 79%
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“…42 PAH has high toxicity toward various mammalian cells. 43 Although chitosan has good biocompatibility and antibacterial activity, 44 its physical properties are highly pH dependent. 45 To overcome the poor solubility, water soluble oligochitosan has been made by hydrolysis of chitosan.…”
Section: Introductionmentioning
confidence: 99%