Synthesis of stimuli-responsive and adsorbable block copolymers with phosphonate anchor groups

Kuckling, Dirk; Moosmann, Katrin; Schier, Jan E. S.; Britze, Antje

doi:10.1007/s00396-012-2878-5

Cited by 3 publications

(2 citation statements)

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“…As titanium samples carry a native oxide layer, we used titanium oxide particles to investigate the affinity of polymer to the metal surface from methanolic solutions at different concentrations. [ 23 ] Phosphonic acid groups react with surface hydroxyl groups to form M‐O‐P bonds, covalently anchoring the polymer to the particle. Visually, the adsorption becomes evident as the coated particles behave like a stable dispersion for several hours up to days, whereas the pristine titanium oxide particles settle without stirring in a shorter timeframe.…”

Section: Resultsmentioning

confidence: 99%

“…Conducting time-dependent measurements, kinetic phenomena like adsorption and desorption can be monitored. [23,32] The substrate is LaSFN9-glass coated with chromium (≈1 nm), gold (≈50 nm), and titanium oxide (≈4 nm). p(VPPr 65 -b-PA 16 ) was chosen as a representative sample due to its high grafting density and water solubility to prepare the polymer brush on the metal layer via "grafting to".…”

Section: Tablementioning

confidence: 99%

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Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers

Methling

Dückmann

Simon

et al. 2023

Macro Materials & Eng

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Coating medical implants with antibacterial polymers may prevent postoperative infections which are a common issue for conventional titanium implants and can even lead to implant failure. Easily applicable diblock copolymers are presented that form polymer brushes via “grafting to” mechanism on titanium and equip the modified material with antibacterial properties. The polymers carry quaternized pyridinium units to combat bacteria and phosphonic acid groups which allow the linear chains to be anchored to metal surfaces in a convenient coating process. The polymers are synthesized via reversible‐addition‐fragmentation‐chain‐transfer (RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy and SEC. Low grafting densities are a major drawback of the “grafting to” approach compared to “grafting from”. Thus, the number of phosphonic acid groups in the anchor block are varied to investigate and optimize the surface binding. Modified titanium surfaces are examined regarding their composition, wetting behavior, streaming potential, and coating stability. Evaluation of the antimicrobial properties revealed reduced bacterial adhesion and biofilm formation for certain polymers, albeit the cell biocompatibility against human gingival fibroblasts is also impaired. The presented findings show the potential of easy‐to‐apply polymer coatings and aid in designing next‐generation implant surface modifications.

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Section: Resultsmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%