Synthesis of Stereodefined Polysubstituted Bicyclo[1.1.0]butanes
Rahul Suresh,
Noam Orbach,
Ilan Marek
Abstract:We report a highly diastereoselective synthesis of polysubstituted
bicyclobutanes possessing up to three stereodefined quaternary centers
and five substituents. Our strategy involves a diastereoselective
carbometalation of cyclopropenes followed by a cyclization to furnish
the bicyclobutane ring system. This straightforward approach allows
for the incorporation of a diverse range of substituents and functional
groups, notably without the need for electron-withdrawing functionalities.
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