Synthesis of Spirocyclohexadienones via Palladium-Catalyzed Dearomatization of Dibenzoxaborins
Yuyao Zhao,
Lincong Sun,
Junbiao Chang
et al.
Abstract:The development of Pd(II)-catalyzed dearomatization transformation of dibenzoxaborins with alkynes triggered by transmetalation from boron to palladium has been achieved, leading to the synthesis of spirocyclohexadienones, an important skeleton demonstrating potential biomedical utility. The [3 + 2] spiroannulation exhibits remarkable regioselectivity and broad substrate scope under mild reaction conditions. This methodology employs dibenzoxaborin as a substrate to establish the formal dearomatization of 2-phe… Show more
The Fe(OTf)3-promoted directing group-controlled regioselective C–H borylation of 2-arylarenolic compounds was achieved at room temperature, affording two useful arylboronic acids efficiently.
The Fe(OTf)3-promoted directing group-controlled regioselective C–H borylation of 2-arylarenolic compounds was achieved at room temperature, affording two useful arylboronic acids efficiently.
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