Synthesis of Spiro 1,3-Oxazines via Three-Component Reaction of Conjugated Imines, Dialkyl Acetylenedicarboxylates and N,N'-Disubstituted Parabanic Acids

Abstract

Synthesis of spiro 1,3-oxazines via three-component reaction of conjugated imines, dialkyl acetylenedicarboxylates and N,N'-disubstituted parabanic acids

Recent advances in the application of alkynes in multicomponent reactions

“…Asghari and co-workers 68 synthesized spiro 1,3-oxazines 110 via the reaction among N , N ′-disubstituted parabanic acid derivatives 109, imine derivatives 107, and dialkyl acetylenedicarboxylate derivatives (DAAD) 108 in dry dichloromethane without catalyst at room temperature for 1–6 h ( Scheme 49 ).…”