Synthesis of Some Substituted Benzimidazolones

Clark, Robert L.; Pessolano, A. A.

doi:10.1021/ja01540a037

Cited by 54 publications

(11 citation statements)

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“…Similar hydrolysis reactions of carbenes to imidazolones are reported [24]. The substituted benzimidazolones are crucial precursors to many pharmacologically active compounds [25]. Compounds 10ae10g were characterized by 1 H NMR spectroscopy.…”

Section: Synthesismentioning

confidence: 57%

Facile synthesis of benzimidazolin-2-chalcogenones: Nature of the carbon–chalcogen bond

Manjare

Sharma

Singh

et al. 2012

Journal of Organometallic Chemistry

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Section: Synthesismentioning

confidence: 57%

Facile synthesis of benzimidazolin-2-chalcogenones: Nature of the carbon–chalcogen bond

Manjare

Sharma

Singh

et al. 2012

Journal of Organometallic Chemistry

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“…Compound 133h was produced by fusion of o-phenylenediamine with urea [65], followed by nitration by a mixture of nitric acid and sulfuric acid, and then reduction by iron [3]. Compound 134h was produced by similar approach, in the first stage o-phenylenediamine being fused with oxalic acid [66].…”

Section: + -+mentioning

confidence: 99%

A review on synthesis of nitrogen-containing heterocyclic dyes for textile fibers - Part 2: Fused heterocycles

Khattab

Rehan

2018

Egypt. J. Chem.

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I MPORTANCE of heterocyclic dyes has recently increased due to their deep shades, high tentorial strength, excellent colorfastness and brightness compared to azobenzene analogous. Development of novel synthetic approaches for fused heterocyclic dyes has remained a highly interesting but challenging proposition. An overview of the application of nitrogen-containing fused heterocyclic dyestuffs for textile coloration is presented. In this review, we provide details outlining the synthesis of recently prepared fused nitrogen-containing heterocyclic dyestuffs and their dyeing efficiency on textile fibers.

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“…Compound 18 a was prepared according to Clark [23] and Kloetzel [16] . For the synthesis of 18 b 5-chloro-2,3-dihydro-1H-benzo[d]imidazole-2-one was synthesized as follows: 80 mmol 4-chloro-o-phenylenediamine and 80 mmol 1,1′-carbonyldiimidazole were dissolved in 400 ml dry tetrahydrofuran each and added dropwise to 150 ml dry tetrahydrofuran.…”

Section: 3-bis-substituted Benzimidazole-2-ones 18 Abmentioning

confidence: 99%

Benzimidazoles as NMDA Glycine-Site Antagonists: Study on the Structural Requirements in 2-Position of the Ligand

Dannhardt¹,

Kohl

2000

Arch. Pharm. Pharm. Med. Chem.

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A series of different substituted benzimidazole derivatives has been synthesized and evaluated for the ability to displace [ 3 H]MDL‐105,519 to rat cortical membranes. Two benzimid‐azole‐ 2‐carboxylic acids 9 b and 9 c, in this substitution pattern not yet described as glycine antagonists, showed IC50 values of 0.89 μM (9 b) and 38.0 μM (9 c). Replacement of the carboxylate function in 2‐position by a sulfonic acid moiety appreciably increased solubility, but decreased the affinity giving evidence for the strong need of the carboxylate group within the ligand. Further structure‐activity studies using benzimidazol‐2‐one derivatives with an acetic acid moiety adjacent to a ring nitrogen revealed new insights into the importance of amide functionalities within the heterocycle for the affinity of antagonist glycine‐site ligands

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Synthesis of Some Substituted Benzimidazolones

Cited by 54 publications

References 0 publications

Facile synthesis of benzimidazolin-2-chalcogenones: Nature of the carbon–chalcogen bond

Facile synthesis of benzimidazolin-2-chalcogenones: Nature of the carbon–chalcogen bond

A review on synthesis of nitrogen-containing heterocyclic dyes for textile fibers - Part 2: Fused heterocycles

Benzimidazoles as NMDA Glycine-Site Antagonists: Study on the Structural Requirements in 2-Position of the Ligand

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