Synthesis of Some Salicylaldehyde‐Based Schiff Bases in Aqueous Media

Abstract

A new efficient and environmental friendly procedure for the synthesis of a series of salicylaldehyde-based schiff bases under microwave irradiation is described. The method is compared with the conventional method also. The present work involves condensation of salicylaldehyde with various aromatic amines in water under microwave irradiation. A judicious choice of the solvent and reaction conditions allowed the final products to be generated in excellent yields in a one-step procedure, whereas experiments under thermal conditions led to lower yields with tedious work-up. Microwave irradiation method gives advantages like reduction in reaction time, increase in conversion, reduced wastes, and good yields. The structures of synthesized compounds were confirmed by IR, 1HNMR, and Mass Spectra data.

In Silico Studies, Comparative Synthesis and Antibacterial Activity of Some Imine Derivatives of Isonicotinic Hydrazide

“…The starting materials utilized for the synthesis are all white powders and crystals therefore the change in color shows that a likely chromophore has been formed given the product it characteristic color. This corresponds with several other researches where Schiff bases are reported as yellow in color [6,15,16]. This could also explain the reason dimethylamino benzaldehyde is used as reagents for derivatization and identification of alkaloids and saponins in plant samples [17] (Figures 1 & 2).…”

Arylidene Derivatives as Synthons in Heterocyclic Synthesis

“…The reaction was also carried out in ethanol at room temperature [229] [230], in refluxing ethanol [231], in refluxing ethanol and in the presence of a catalytic amount of glacial acetic acid [222] [232], in refluxing methanol and in the presence of a catalytic amount of glacial acetic acid [233], in methanol at room temperature and in the presence of a catalytic amount of concentrated hydrochloric acid [234], in refluxing ethanol and in the presence of a catalytic amount of concentrated sulfuric acid [235], in refluxing mixture of ethanol/dioxane and in the presence of a catalytic amount of glacial acetic acid [236], in refluxing ethanol and in the presence of a catalytic amount of anhydrous zinc chloride [237], in refluxing benzene [238], in dichloromethane (DCM) at room temperature and in the presence of anhydrous magnesium sulfate [238], using DCM and a catalytic amount of neutral alumina under microwave irradiation [238], under solvent-free conditions in the presence of lemon juice as natural acid catalyst [239], in refluxing methanol and in the presence of a catalytic amount of nickel nitrate [240], and using phosphorus pentoxide/silica gel (P 2 O 5 /SiO 2 ) [241]. In addition, a green and efficient method for the synthesis of Schiff bases in aqueous media was described [242].…”

New Schiff Base Crystal Ligand type [NO 2 ] derived from the interacting of 2-aminophenol with Glyoxylic acid, and its [N 2 O 4 ] Mn п Complex, Synthesizing and Characterizing

“…The condensation of salicylaldehyde with various aromatic amines in water under microwave irradiation. A judicious choice of the solvent and reaction conditions allowed the final products to be generated in excellent yields in a one-step procedure, whereas experiments under thermal conditions led to lower yields with tedious work-up [17]. The Schiff bases are widely used for industrial purposes and also exhibit a broad range of biological activities.…”