Synthesis of Some of Fluorinated Benzimidazole Nucleosides

Break, Laila M.

doi:10.5539/ijc.v8n1p188

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…The ten signals of carbon were assigned to two of the sugar moieties (see the Experimental section). The 13 C NMR of the CF3 group showed at δ121.54, 104.87 and 108.52 of Compounds 3, 6, and 7, respectively Mass: M + 493.01, 173.04 (100%) [8,9].…”

Section: Resultsmentioning

confidence: 99%

Synthesis New of Nucleoside of 1,3-bis-(2,3,5-tri-O-Benzoyl-β-D-Ribofuranosyl)-8-(Trifluoromethyl)-2-Methyl-4-Quinazolinone

Break¹,

Al-harthi²

2018

22nd International Electronic Conference on Synthetic Organic Chemistry

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Fluorinated nucleosides are very important for increased biological and chemical stability of organ fluorine compounds. Synthesis of (1H)-8-trifluloromethyl-2-methyl-4-quinazolinone 3 from 2-amino-3-(trifluoromethyl) benzoic acid 1 was performed. Ribosylation of compound 4 with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-d-ribofuranose 5 using the silylation method created the benzoylated nucleoside derivative 6. Debenzoylation of the protected nucleoside 6 via reaction with sodium metal in dry methanol to create the corresponding free nucleoside 1,3-bis-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-8-(trifluoromethyl)-2-methyl-4-quinazolinone 7. The structures of the newly synthesis compounds have been confirmed on the basis of IR, 1HNMR, 13CNMR, and mass spectral data.

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Section: Resultsmentioning

confidence: 99%

Synthesis New of Nucleoside of 1,3-bis-(2,3,5-tri-O-Benzoyl-β-D-Ribofuranosyl)-8-(Trifluoromethyl)-2-Methyl-4-Quinazolinone

Break¹,

Al-harthi²

2018

22nd International Electronic Conference on Synthetic Organic Chemistry

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“…The five signals were assigned to C-1', C-2', C-3', C-4', and C-5' of the sugar moiety, at δ 89.52 C 1`, 76.47 C 2`, 74.93 C 3`, 71.98 C 4` and 63.82 C 5` for compound 5, and at δ 89.89 C 1`, 79.31 C 2`, 76.41 C 3`, 69.29 C 4`, 61.63 C 5` for compound 6. The 13 C NMR of CF 3 group showed at δ119.80, 119.32 and 118.96 of compounds 2, 5 and 6 respectively (Break, 2016 andBreak,2015. 13 CNMR shifts of C=S group: those of derivatives 2, 5, and 6 lie in the region of 188.2, 189.2 and 190.1 ppm, respectively that of thion groups. (Hanusek J., et al;2001).…”

Section: Resultsmentioning

confidence: 99%

Synthesis of 8-Trifluloromethyl-2-Thioquinazolin-(3H)-4-One Nucleosides

Break¹

2017

IJC

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Synthesis of 8-trifluloromethyl-2-thioquinazolin-(1H,3H)-4-one 2. which have been ribosylated by coupling with 1-O-acetyl-2,3,5-tri-O-benzoyl--D-ribofuranose 4 by using the silylation method, afforded β-anomeric of the benzoylated nucleoside derivatives 5. Debenzoylation of 5 by sodium metal in dry methanol to afford the corresponding free nucleosides 6. The structures of the newly synthesis compounds have been confirmed on the basis of elemental analyses, IR, 1 HNMR, 13CNMR and Mass spectral data.

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“…After reducing the azido group of nucleosides 72 with hydrogen on Raney nickel, the resulting compound, 2-Amino-5,6-dichloro-1-(2-deoxy-D-erythro-pentofuranosyl) benzimidazole (9a), could be obtained. 29…”

Section: Methodsmentioning

confidence: 99%

Study on Benzimidazole: A Comprehensive Review

-¹,

-²,

-³

et al. 2023

IJFMR

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The chemical compound known as benzimidazole has been assigned to the category of heterocyclic aromatic in one of the potential classifications for it. This structure has a notable pharmacophore position in the scientific discipline of medicinal chemistry and enjoys a privileged status within that discipline. As a result of the fact that it possesses a wide range of beneficial therapeutic effects, such as those of antiulcerants, antihypertensives, analgesics, edicines, antivirals, antifungals, anticancer, and antihistamines, it serves a very important purpose. This is due to the fact that it has a very important purpose. The literature review reveals that benzimidazole derivatives are effective chemicals, and a wide range of reviews that are currently available on the market for organic chemistry and medical specialist studies have confirmed that the molecules of these compounds are helpful against a variety of different microorganisms. The importance of the methodology used in its synthesis has piqued the curiosity of synthetic organic chemists, who have shown an interest in the processes involved. As a direct result of this, we have made an effort in our evaluation of the gift to assemble information on the chemistry that lies behind a wide variety of substituted benzimidazole byproducts and the many medicinal applications of these substances.

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Synthesis of Some of Fluorinated Benzimidazole Nucleosides

Cited by 5 publications

References 14 publications

Synthesis New of Nucleoside of 1,3-bis-(2,3,5-tri-O-Benzoyl-β-D-Ribofuranosyl)-8-(Trifluoromethyl)-2-Methyl-4-Quinazolinone

Synthesis New of Nucleoside of 1,3-bis-(2,3,5-tri-O-Benzoyl-β-D-Ribofuranosyl)-8-(Trifluoromethyl)-2-Methyl-4-Quinazolinone

Synthesis of 8-Trifluloromethyl-2-Thioquinazolin-(3H)-4-One Nucleosides

Study on Benzimidazole: A Comprehensive Review

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