Synthesis of some novel pyrano[2,3-f]chromenone derivatives

Synthesis and molecular docking studies of new chromane (2-(4-hydroxybenzyl) 3,5,7-trihydroxychroma-4-one) and its O-substituted analogues

“…Among the widespread heterocyclic molecules, the oxygen heterobicycles like chroman-4-one/Chromanone occupy a privileged place because of their extensive natural abundance as flavonols, flavone, flavanone, isoflavone and homisoflavonones with broad spectrum biological as well as pharmaceutical significance [1][2][3]. In the precise classes of chromane, 'chroman-4-one' scaffold represent a privileged nucleus well distributed in natural products with a broad spectrum of potent biological activities like anticancer, tumour necrosis factor-α (TNF-α) inhibitors, antidiabetic, antioxidant, antivascular, antifungal, antimicrobial, antiviral, insecticidal, antileishmanial, spasmolytic, analgesic, antiinflammatory, estrogenic inhibitor, anti-acetylcholinesterase and anticoagulant activity [4].…”

“…Generally, the presence of chromane ring-based structure in a molecule is often associated with its potency to prevent diseases. Moreover numerous synthetic derivatives of naturally occurring chromane such as hesperitin [6], Violacin A [7], dihydromyricetin [8], stilbin [9], silybin [10], 4'-O-Dimethylophiopogonanone E [11], Novel (E)-5,7dimethoxy-3-(4'-hydroxybenzylidene) chroman-4-one [7], 3-arylidene-7methoxychroman-4-one, Dihydroflavonols [3,5,7-Trihydroxy-2-(4′-fuorophenyl) chroman-4-one], [3,5,7-Trihydroxy-2-(pyridin-3-yl) chroman-4-one], [3,5,6,7-Tetrahydroxy-2-(3′,4′-dihydroxyphenyl) chroman-4-one] [12], Homoisoflavones [(R)-3-(3,4-Dihydroxybenzyl)-7-hydroxy-5-methoxychroman-4-one],…”

New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents

“…Chromanone and its analogs are also important pharmacophores and privileged structures in medicinal chemistry and have featured in a number of clinically used drugs (Keri et al, 2014, Emami and Ghanbarimasir, 2015), especially, as anticancer agents (Seifert et al, 2014, Lampronti et al, 2003, Gamal-Eldeen et al, 2009, Alizadeh et al, 2015). Furthermore, various chromenes (Fig.…”

Synthesis of Novel 1,2,3-Triazole-dihydro[3,2-c]chromenones as Acetylcholinesterase Inhibitors

“…However, literature lacks efficient and versatile procedures for the construction of 1,2,3-triazole-chromenone scaffolds. [24] As part of our activities on the synthesis of novel heterocycles as well as bioactive compounds, [25][26][27][28] we have specially focused on the anti-Alzheimer agents acting via inhibition of AChE enzyme. Alzheimer's disease (AD) is known as the main origin of dementia among older people.…”