Synthesis of some novel purine derivatives incorporating tetrazole ring and investigation of their antimicrobial activity and DNA interactions

Kinali-Demirci, Selin; İdil, Önder; Dişli, Ali

doi:10.1007/s00044-014-1209-4

Cited by 10 publications

(2 citation statements)

References 29 publications

(28 reference statements)

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“…Purine is an aromatic heterocycle compound consisting of two fused rings. Purine derivatives have exhibited significant pharmaceutical activities such as anticancer, anti-HIV-1, and antimicrobial properties [ 68 , 69 , 70 , 71 , 72 ]. Purine and pyrimidine-based entities are essential natural heterocyclic compounds that have a critical role in several metabolic and cellular conversion processes in deoxyguanosine monophosphate (DGMP) nucleotide (AMP).…”

Section: Hsp90 Inhibitorsmentioning

confidence: 99%

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

et al. 2022

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Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation, and conformation of proteins as well as their effects on prevention of protein aggregation. Hsp90 ensures the stability of various client proteins needed for the growth of cells or the survival of tumor cells; therefore, they are overexpressed in tumor cells and play key roles in carcinogenesis. Accordingly, Hsp90 inhibitors are recognized as attractive therapeutic agents for investigations pertaining to tumor suppression. Natural Hsp90 inhibitors comprising geldanamycin (GM), reclaimed analogs of GM including 17-AAG and DMAG, and radicicol, a natural macrocyclic antifungal, are among the first potent Hsp90 inhibitors. Herein, recently synthesized heterocyclic compounds recognized as potent Hsp90 inhibitors are reviewed along with the anticancer effects of heterocyclic compounds, comprising purine, pyrazole, triazine, quinolines, coumarin, and isoxazoles molecules.

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Section: Hsp90 Inhibitorsmentioning

confidence: 99%

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

et al. 2022

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“…[16,17] In our previous work, purine derivatives that had a tetrazole ring showed DNA damage and higher antibacterial activities compared to cyano compounds. [18] Tetrazoles, a well-described class of nitrogen-containing heterocycles, have shown valuable properties with a wide range of applications in materials science and beyond, including catalysis, propellants, information recording systems, explosives, and with possible applications in high-energy chemistry. [19][20][21][22][23] Pharmaceutical chemistry has produced many drugs containing a tetrazole ring as a structural element (in order to treat, AIDS, cancer and tuberculosis for example).…”

Section: Introductionmentioning

confidence: 99%

Adenine Derivatives for Regenerable Antibacterial Surface Applications Based on A−T Base Pairing

et al. 2020

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Surface contamination is a major concern in the design, fabrication, and application of biomaterials. In this work, a series of new adenine derivatives were synthesized in a three‐step method with the goal of protecting the functional materials against microbial adhesion. Initially, 9‐(chloroalkyl)‐9H‐purin‐6‐amine compounds were synthesized from adenine. Then, these compounds were reacted with potassium thiocyanate or potassium selenocyanate. In the last step, adenine derivatives incorporating a tetrazole ring were synthesized via the cycloaddition of sodium azide with thiocyano or selenocyano derivatives. The antimicrobial activity of the compounds was evaluated by using the minimal inhibitory concentration method. Furthermore, the effect of the compounds on pBR322 plasmid DNA was studied using gel electrophoretic mobility measurements. The antimicrobial assay showed that some of the synthesized compounds exerted vigorous antibacterial and antifungal activities. Further experiments indicated that seleno‐adenine derivatives have higher antimicrobial and DNA effect than other derivatives. The surfaces activated by the adenine derivative demonstrated antibacterial activity resisting bacterial attachment in order to remove dead bacteria from the surface. All results showed that some of these adenine derivatives have an antibacterial activity and the potential for further applications, for example as a smart surface coating that prevents bacterial adhesion to biomaterials.

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Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity

Łukowska-Chojnacka

Mierzejewska

Milner-Krawczyk

et al. 2016

Bioorganic & Medicinal Chemistry

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Synthesis of some novel purine derivatives incorporating tetrazole ring and investigation of their antimicrobial activity and DNA interactions

Cited by 10 publications

References 29 publications

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

Adenine Derivatives for Regenerable Antibacterial Surface Applications Based on A−T Base Pairing

Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity

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