Synthesis of some novel dicoumarol derivatives

l-Proline-catalysed synthesis of chromeno[2,3-b]chromene from 4-hydroxy-2H-chromene-2-thione and an anti-proliferative study

“…The chemistry of 4-hydroxycoumarin was explored extensively for new compounds, including warfarin, dicoumarol, and flocoumafen, which have significant pharmacological importance and are used as anticoagulants in medicine. [15][16][17][18][19] In contrast, the chemistry of 4-hydroxy-2Hchromene-2-thione (VI), a sulphur-containing analogue of 4-hydroxycoumarin, is far less explored than that of 4-hydroxycoumarin (IV). 20,21 However, 4-hydroxydithiocoumarin (V) and 4-hydroxy-2H-thiochromen-2-one (VII) are two well-studied molecules (Fig.…”