Synthesis of Some Novel Acyclolumazine N-1 Nucleosides

N‐ and C‐acyclic thionuleoside analogues of 1,2,3‐triazole

“…CH 2 -1 appeared as singlets at δ 5.30, 5.35, and 5.38, respectively. The lower field triplets at δ 2.83, 2.78, and 2.89 were attributed to CH 2 -3 , because of the influence of sulfur atom in comparison to those of the oxygen analogues [17,18]. The triplets (J 6.0 Hz) at δ 3.89, 3.75, and 3.91 were assigned to CH 2 -4 , respectively.…”

“…A review of acyclonucleosides appeared recently [16]. In connection with our synthetic approaches on the synthesis of acyclic N-and C-nucleosides [17][18][19][20] and the 1,2,3-triazoles [21] and their carbamate analogues [22], we herein report on the synthesis of novel acyclic 1,2,3-triazole Nthionucleoside analogues bearing 1,2,3-triazole ring carrying potential halomethyl and carbamate groups in addition to their rearrangement to the C-thio acyclic analogues via the sulfur participation, as promising antiviral or antineoplastic agents. A few halomethyl nucleoside derivatives have been described with potential cytostatic activity [23,24], such as N-glycosyl(halomethyl)-1,2,3-triazoles [25] and 3-substituted-thymidine analogues [26] as alkylating and antiviral agents, respectively.…”

Thiosugar Nucleosides. Effect of Sulfur in the Synthesis of Substituted Azido‐5‐Thio‐D‐Gluco‐ and Allopyranosyl‐N‐Nucleosides and New Isothionucleoside Derivatives Thereof

“…[31] When 3 was stirred with lithium azide in dimethylformamide, two compounds were identified and separated by chromatography. [31] When 3 was stirred with lithium azide in dimethylformamide, two compounds were identified and separated by chromatography.…”

“…A solution of 3 [31] (500 mg, 0.86 mmol) in dimethylformamide (15 mL) was stirred with lithium azide at 238C for 16 hr. After cooling, the mixture was evaporated to dryness and the residue was partitioned between chloroform (30 mL) and water (4 Â 20 mL).…”

Synthesis and Biological Evaluation of New Dipyridylpteridines, Lumazines, and Related Analogues

“…The capability of pteridines and pterines for simulating the reactivity of metal sites in several enzymes encouraged many laboratories to synthesize the metal complexes of these molecules [28][29][30]. The synthesis of various lumazine nucleosides via multi-step synthesis was a part of our program to explore such type of compounds [31][32][33][34].…”