Synthesis of some new S-glycosyl pyrimidine and condensed pyrimidine derivatives

Ecofriendly synthesis of pyrano[2,3‐d]pyrimidine derivatives and related heterocycles with anti‐inflammatory activities

“…[21] Multicomponent reactions are mostly used in organic synthesis, biological discovery, combinatorial library, and agrochemical synthesis. [22] In connection to our previous studies on the biological activities of pyrimidine and fused derivatives, [23][24][25][26][27] the one-pot reaction has become significant in combinatorial and green chemistry due to its process simplicity, mild conditions, atomic economy, and extension of the scope of substrates. [28] So, the authors decided to synthesize the pyranopyrimidine derivatives through a nanoparticle catalyst, which has revealed broad applications as a facile and efficient method to carry out many organic reactions, producing high yields and higher selectivity, lower quantities of side products, and consequently, easier workup and purification of the products, and designing polyheterocyclic compounds containing five and/or six rings fused with each other so as to obtain a superior biological activity.…”

Synthesis of five membered ring hetero cyclic compounds derived from methyl-6- methyl-2- oxo-4-substituted 1,2,3,4- tetrahydro pyrimidine-5-carboxylate

“…The pyrimidine derivative (4) was obtained from the reaction of ethyl -2-amino-4,5,6,7-tetra hydro-benzothiophene -3-carboxylate (3) with excess formamide (11) . S-glycosyl pyrimdine and condensed pyrimidine derivatives were synthesized from isothiocyanate and acrylate (12) . Some heterocyclic compounds containing pyrimidino-pyrimidine moiety as compound (5) have been synthesized, and these compounds showed antibacterial activity against grampositive and negative species (13) Pyrimidine derivatives as pyrido[2,3-d]pyrimidin -4-(3H)one (6) was synthesized (14) where as condensation of chalcone with thiourea in presence of potassium hydroxide gave 1,6-Dihydropyrimidine-2-thiol which show antibacterial activity (15) .…”