Synthesis of some new pyrimido[2′,1′:2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents

Abu‐Hashem, Ameen A.; Gouda, Moustafa A.; Badria, Farid A.

doi:10.1016/j.ejmech.2010.01.042

Cited by 142 publications

(53 citation statements)

References 14 publications

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“…The 2nd-14th groups were orally administered aqueous suspension of the synthesized compounds (dose; 20 mg/kg) 1 h before carrageenan injection. The last group (standard) was administered diclofenc sodium in a dose of 20 mg/kg, orally as aqueous suspension (Abu-Hashem et al, 2010). The paw volume of each rat was measured immediately by mercury plethysmometer, before carrageenan injection and then hourly for 4-h post administration of aqueous suspension of the synthesized compounds.…”

Section: Animalsmentioning

confidence: 99%

Synthesis, antimicrobial, antioxidant, anti-inflammatory, and analgesic activities of some new 3-(2′-thienyl)pyrazole-based heterocycles

Abdel‐Wahab

Abdel‐Gawad

Awad³

et al. 2011

Med Chem Res

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1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde was used as a synthon for the synthesis of new thiazole and pyrazoline heterocycles having 2-thienylpyrazole moiety. The antimicrobial, anti-inflammatory, and analgesic activities of the synthesized compounds were evaluated using agar diffusion method, carrageenaninduced paw edema, and writhing assays, respectively. It was found that the majority of the tested compounds exhibited both analgesic and anti-inflammatory activities.

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Section: Animalsmentioning

confidence: 99%

Synthesis, antimicrobial, antioxidant, anti-inflammatory, and analgesic activities of some new 3-(2′-thienyl)pyrazole-based heterocycles

Abdel‐Wahab

Abdel‐Gawad

Awad³

et al. 2011

Med Chem Res

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“…Syntheses of quinoxalines have attracted a great deal of attention in view of their potent biological and pharmacological activities including anticonvulsant [1–4], antibacterial [5], antifungal [6], antiviral [7], antitubercular [8], antileishmanial [9], antiamoebic [10], analgesic [11], antihistaminic [12], antineoplastic [13], hypoglycemic [14], MAO-A inhibitor [15], antiarrhythmic [16], antiatherosclerotic [17], antiobese [18], and other diverse pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents

Alswah

Ghiaty

El-Morsy

et al. 2013

ISRN Organic Chemistry

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2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.

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“…In addition to this, studies are performed on coumarin derivatives for their therapeutic role in the treatment of cancer (Lacy and O'Kennedy, 2004). Various pyrimidine derivatives have been reported as anti-microbial (El-Sayed Ali, 2009), analgesic and anti-inflammatory (Amr et al, 2007;Abu-Hashem et al, 2010;El-Gazzar et al, 2009;Chikhale et al, 2009), anticonvulsants (Gupta et al, 2009), anti-HIV (Fujiwara et al, 2008), antiviral (Hockov et al, 2004), anti-tubercular (Ballell et al, 2007), anti-tumor (Wagner et al, 2008), anti-neoplastic (Xie et al, 2009), antioxidant, and radioprotective agents (Ghorab et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Analgesic study of novel pyrimidine derivatives linked with coumarin moiety

Gupta¹,

Sharma²,

Dudhe

et al. 2011

Med Chem Res

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A novel series of 2-amino-4-(coumarin-3-yl)-6-substituted phenyl pyrimidines (5a-h) were synthesized from 3-acetylcoumarin (3). The structures of the synthesized compounds were elucidated by I.R., 1 H NMR, 13 C NMR, and Mass spectroscopic techniques. The synthesized compounds were screened for in vivo analgesic activities at a dose of 20 mg/kg body weight (b.w). Among them, compounds 5b and 5h exhibited significant analgesic activity comparable with control as well as standard drug diclofenac sodium using acetic acid-induced writhing model.

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Synthesis of some new pyrimido[2′,1′:2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents

Cited by 142 publications

References 14 publications

Synthesis, antimicrobial, antioxidant, anti-inflammatory, and analgesic activities of some new 3-(2′-thienyl)pyrazole-based heterocycles

Synthesis, antimicrobial, antioxidant, anti-inflammatory, and analgesic activities of some new 3-(2′-thienyl)pyrazole-based heterocycles

Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents

Analgesic study of novel pyrimidine derivatives linked with coumarin moiety

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