Synthesis of Some New Fluorine Containing 1,3,4-Trisubstituted 4,8-Dihydro-1H-pyraolo[3,4-e][1,4]thiazepin-7(6H)-ones and Related Compounds

One-Step Synthesis of α-Chloro Acetophenones from Acid Chlorides and Aryl Precursors

“…It is interesting to note the positional contrast of several of these products relative to their Friedel−Crafts product. In the case of 1a , the 4-fluoro acetophenone is the product of Friedel−Crafts acylation, as opposed to the 2-fluoro isomer 2a . Similarly, as previously noted, 1b yields the 3,4-difluoro acetophenone instead of the desired 2,3-difluoro isomer.…”