Synthesis of some new derivatives of thiazolopyrimidines and hydrolysis of its arylidene derivative

Abstract

Abstract.A new ammonium acetate-assisted, convenient and efficient procedure for the synthesis of arylidene derivatives of thiazolopyrimidine is described. The main advantages of this protocol is that it is economical, short reaction time, commonly available chemicals, and ease of isolation of products. In addition, a new series of thiazole-fused pyrimidines were synthesized and hydrolysis of one of its arylidene derivative studied. All the compounds were characterized by analytical and spectroscopic methods. Further, the structure of hydrolyzed product and two other compounds were confirmed by X-ray crystal structure analysis. The crystal structures are stabilized by intermolecular C-H. . .O, C-H. . .N, C-H. . . π and π . . . π weak interactions. The anti-microbial screening was done on the compounds in order to test their anti-bacterial and anti-fungal activities.

Synthesis and antimicrobial activity of new 1,2,3,4-tetrahydropyrimidine-5-carbonyl glycinate silver nanoparticle derivatives

“…The resultant mixture was placed into a separator funnel and rinsed three times with 5% sodium bicarbonate, 5% HCl solution three times, and finally washed with D.W. three times. The organic layer was then dehydrated with MgSO4, and The crude precipitating product was recovered and cleaned with 40-60% petroleum ether, n-hexan, and lastly pure material was produced by recrystallization from ethanol using a rotary evaporator (15).…”

Synthesis, Molecular Modelling and Biological Evaluation of Novel Pyrimidine Derivatives as Anti-inflammatory Agents

“…Their 1 H-NMR showed singlet at 8.8-11.6 ppm corresponding to the D 2 O exchangeable protons of 2NH of the pyrimidine ring. Pyrimidine-2-thione 1 undergoes Mannich reaction [46,47] with paraformaldehyde and certain primary aromatic amines yielding compounds 3a-d. The mechanism of Mannich reaction starts with the formation of an iminium ion from the amine and the formaldehyde.…”

Novel One-pot Synthesis of Thiazolo[3,2-a] Pyrimidin-5-one as a Key Compound for Poly Nuclear Heterocycles

“…The IR spectra were recorded (KBr) on a Perkin-Elmer 1430 spectrometer (National Research Centre). The 1 H-NMR and 13 C-NMR spectra were recorded in δ ppm scale on Jeol ECA 500 spectrometer, run at 500 MHz for 1 H-NMR and 125 MHz for 13 C-NMR (National Research Centre) with TMS (SiMe 4 ) as internal standard. The coupling constant values are reported in Hz.…”

“…They receive diverse pharmacological applications such as anti-HIV (5,6) , antibacterial (7,8) , anticancer (9) , anti-inflammatory (10)(11)(12) , antimalarial (5) , antimicrobial (12,13) , anti-HSV-1 (14) and herbicidal (15) activities. Furthermore, some thiazolopyrimidines have been assigned as new acetylcholin esterase inhibitors, especially for the treatment of Alzheimer's disease (16) .…”