Synthesis of some new biologically active coumarin derivatives

Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives

“…The resulted solid was filtered off. The crude product thus obtained was purified by column chromatography on silica gel with hexane-ethyl acetate as eluent to afford corresponding 2-arylamino-8-fluoro- [1,3,4] 167.2, 160.2, 159.8, 155.2, 151.4, 144.8, 141.0, 135.3, 129.8, 126.3, 125.7, 124.7, 122.3, 120.7, 119.7, 118.7, 115.6 …”

“…The quinoline skeleton is often used for the design of many synthetic compounds with diverse pharmacological properties such as anti-inflammatory [1], antimicrobial [2], cytotoxic [3], antitumor [4], antimalarial [5], anti-cancer [6], HIV protease inhibitor [7] and anti-viral [8] activities. It is known that many 1,3,4-thiadiazoles have biological activities like antibacterial [9], antimycobacterial [10], antimycotic [11], antifungal [12], antidepression [13], analgesic [14] and anti-inflammatory [15].…”

A Simple Synthesis of Functionalized 3‐Bromocoumarins by a One‐Pot Three‐Component Reaction

“…The spectroscopic data are in agreement with those published in the literature. [26] Compound 7: Yield 30 % (51 mg). The spectroscopic data are in agreement with those published in the literature.…”

“…Since the first isolation of coumarin in 1820, over 1400 natural coumarins have been isolated. [1] The coumarin ring system is a useful structure in heterocyclic synthesis and it displays a variety of important biological activities, including anti-coagulation, antibiotic, [2] anti-psoriasis, anti-HIV [3] and anti-tumour activities. [4] 3,8-Dibromo-7-hydroxy-4-methylchromen-2-one (DBC), [5] the most promising inhibitor of Casein kinase 2 (CK2), and calanolide A, [6] which inhibits HIV-1 replication, are examples of bioactive substituted 2H-chromen-2-ones.…”

Clean Procedure and DFT Study for the Synthesis of 2-Amino-3-ethoxycarbonyl-4-(aryl)-4H-pyrano-[3,2-c]-chromene-5-ones Derivatives: A Novel Class of Potential Antimicrobial and Antioxidant Agents

“…Novobiocin and chlorobiocin are established antimicrobials containing a coumarin skeleton [4]. Many of these compounds have proved to be active as antibacterial [5][6][7], antifungal [8], anti-in�ammatory [9], anticoagulant [10], anti-HIV [11] and antitumor [12]; In addition, these compounds are used as additives to food and cosmetics [13]. Coumarin derivatives are commonly used as optical whiteners, luminescence dyes [14], active media for lasers [15] and solar collectors [16].…”