Synthesis of some New 4,6-Diaryl-5-aroyl-2-imino-6H- 2,3-dihydro-1 ,3-thiazines

In present report novel thiazines were prepared from starting materials chalcone and thiourea. The resulting compound 6-(4-methoxyphenyl) 4-phenyl-6H-1, 3-thiazin-2-amine (2) was further reacted with ethyl 2-cyano-3, 3-bis (methylthio) acrylate in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 2-(4-methoxyphenyl) 8-(methylthio)-6-0xo-4-phenyl-4, 6, 9, 9a-tetrahydropyrimido [2, 1-b] [1, 3]-thiazine-7-carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH 3) group at 8 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 2-(4-methoxyphenyl)-8-substituted-6-oxo-4-phenyl-4, 6, 9, 9a-tetrahydropyrimido [2, 1-b] [1, 3] thiazine-7-carbonitrile in good yields.

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Synthesis of some New 4,6-Diaryl-5-aroyl-2-imino-6H- 2,3-dihydro-1 ,3-thiazines

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ChemInform Abstract: Synthesis of Some New 4,6‐Diaryl‐5‐aroyl‐2‐imino‐6H‐2,3‐dihydro‐1,3‐ thiazines.

ChemInform Abstract: Synthesis of Some New 4,6‐Diaryl‐5‐aroyl‐2‐imino‐6H‐2,3‐dihydro‐1,3‐ thiazines.

Synthesis of Novel Pyrimido Thiazine and Their Derivatives

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