Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents

A retrospect on antimicrobial potential of thiazole scaffold

“…From the condensation of different 2‐fluoroquinoline‐3‐carbaldehyde, enaminones and malononitrile or ethylcyanoacetate, Raj and coworker synthesized 2′‐amino‐2‐fluoro‐5′‐oxo‐1′‐(4‐phenylthiazol‐2‐yl)‐1′,4′,5′,6′,7′,8′‐hexahydro‐3,4′‐biquinoline‐3′‐carbonitrile derivatives. By broth microdilution method, the synthesized compounds were studied against Streptococcus pneumoniae , Bacillus subtilus , Clostridium tetani , E. coli , S. typhi , V. cholerae , C. albicans and A. fumigates for antimicrobial activity.…”

Cu(II)-Catalyzed 6π-Photocyclization of Dienynes

“…It has a rich history. Since Srimivansan reported the first example in 1963, numerous achievements have been reported in this field . In modern organic chemistry, such reactions provide attractive methods for the preparation of cyclohexa-1,3-diene derivatives, which have found wide applications in the synthesis of various medicines, functionalized materials, and building blocks for organic synthesis .…”

“…It is well-known that the 6π-photocyclization reaction proceeds via two key steps: the formation of a six-membered cyclic transition state and the following intramolecular 1,5-H shift . In a conjugated triene system, it is quite easy to meet the above requirements (Scheme a) . When a dienyne substrate is irradiated under ultraviolet light, an unstable allene intermediate might be generated in situ .…”