Synthesis of some N-hydroxycinnamamide and N-hydroxybenzamide Derivatives Bearing Amide Bonds Targeting HDAC
Nguyen Cuong Quoc,
Le Dang Quang,
Nguyen Duy Tuan
et al.
Abstract:Recently, hydroxamic acid has attracted considerable interest because of its ability to inhibit a variety of metal-containing enzymes such as metalloproteases, lipoxygenases, histone deacetylases, and cancer cells. For example, hydroxamic acid derivatives (vorinostat, belinostat, givinostat, panobinostat) have been approved by the US FDA for the treatment of various cancers. Based on the N-hydroxycinnamamide and N-hydroxybenzamide framework, the study described and synthesized N-hydroxycinnamamide and N-hydrox… Show more
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