Synthesis of Some N-(4-(Aryl)-2-Thioxo-1,3-Thiazol-3(2H)-yl)Pyridine-4- Carboxamide as Antimicrobial and Anti-inflammatory Agents

Synthesis and In Vitro and In Vivo Biological Activity Evaluation and Quantitative Proteome Profiling of Oxadiazoles Bearing Flexible Heterocyclic Patterns

“…A molecular framework that can be developed into a commercial agent should normally have the following features: (1) highly efficient pharmacological activity; (2) mostly having a simple molecular structure; (3) easily obtained or synthesized; (4) permissible biocompatibility and degradability; (5) specific toward the target species; (6) good environmental friendliness; (7) low cytotoxicity toward nontarget organisms; and (8) negligible residues. − To satisfy these modern requirements for the development of agrochemicals, the rational selection of bioactive fragments or intermediates from existing commercial drugs as building blocks may promote the rapid discovery of prospective candidates to fight against microbial diseases due to their unique superiority in manufacture industry, highlighted biological effects, and exclusive privileges toward action targets. − Elaborate investigations found that pyridine and substituted pyridine substructures were often observed in agrochemicals, pharmaceuticals, and natural products because of their multifunctional and privileged features. − Their derivatives have distinct pharmacological activities substantially applied to many fields (Figure a). For example, chlorpyrifos bearing a 3,5,6-trichloropyridin-2-yl pattern has been used as an insecticide to kill various pests with chewing and piercing-sucking mouthparts.…”