Synthesis of Some Mannich Bases and Novel Benzofuran Derivatives Containing Imidazo[2,1-b][1,3,4]thiadiazoles as Biological Agents

Bhovi, Venkatesh K.; Bodke, Yadav D.

doi:10.2174/187231310791170757

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During recent years, there have been intense investigations on thiadiazole and imidazo [2,1-b] [1,3,4]thiadiazole compounds, many of which are known to possess interesting pharmacological properties such as anticancer [7], antitubercular [8], antibacterial [9], antifungal [10], antimicrobial and anti-inflammatory [11,12], analgesic and antimicrobial [13], anticonvulsant, analgesic [14], and antisecretory [15] activities. Moreover, much interest has also been focused on the cardiotonic [16], diuretic [17] and herbicidal [18] activities displayed by compounds incorporating this heterocyclic system.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives

Alegaon¹,

Alagawadi²

2011

Eur. J. Chem.

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives

Alegaon¹,

Alagawadi²

2011

Eur. J. Chem.

View full text Add to dashboard Cite

“…5-Phenyl-1,3,4-thiadiazole is familiar group of bioactive compounds with numerous pharmacological activities 4 . Various pharmacological activities reported for 1,3,4-thiadiazole analogues are anticancer [5][6][7] antimicrobial [8][9][10] , antitubercular 11,12 , anti-inflammatory 13 , analgesic 14 , anticonvulsant 15 , antihypertensive 16 , diuretic 17 , local anesthetic 18 and antioxidant activities 19 .Hence, it is envisaged to synthesize 1,3,4-thiadiazole analogs and screened them for antimicrobial and anticancer activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antimicrobial and Anticancer Activities of 5-(4-Substituted-Phenyl)-1,3,4- Thiadiazole-2-Amines

2017

Rasayan J Chem

View full text Add to dashboard Cite

A series of 5-(4-substituted phenyl)-1,3,4-thiadiazole-2-amines (4a-h) were prepared from dehydrocyclization of 4-substituted benzoyl thiosemicarbazides (3a-h) using concentrated sulphuric acid. The chemical structures of compounds were elucidated by Infra-red, NMR, Mass spectral and elemental analyses. Antibacterial activities of these compounds against Staphylococcus aureus, Bacillus substilis, Eschereria coli and Pseudomonas aeruginosa using Ciprofloxacin while antifungal activities against Aspergillus niger and Candida albicans using Fluconazole as standard drugs were performed. Minimum inhibitory concentrations and anticancer activity of potent compounds was determined. The results indicate that compounds 4(a), 4(b) and 4(c) possess significant antibacterial activity whereas compounds 4(f) and 4(g) possess significant antifungal activity among the series of synthesized thiadiazoles comparing with standard drugs. Further, the results of anticancer studies on breast cancer cell line suggested that some potent antimicrobials i.e. 4(c), 4(f) and 4(g) associated with moderate to good anticancer activity. Thus, it may be found that synthesized compounds have good antibacterial activity and moderate antifungal activity. However, these compounds could be further screened for the antibacterial activities against a battery of bacteria to achieve their broad spectrum profile and also used to screen cytotoxic effect against other cancer cell lines.

show abstract

Synthesis of Some Mannich Bases and Novel Benzofuran Derivatives Containing Imidazo[2,1-b][1,3,4]thiadiazoles as Biological Agents

Cited by 2 publications

References 0 publications

Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives

Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives

Synthesis, Antimicrobial and Anticancer Activities of 5-(4-Substituted-Phenyl)-1,3,4- Thiadiazole-2-Amines

Contact Info

Product

Resources

About