Synthesis of sol-gel mesoporous silica materials providing a slow release of doxorubicin

Abstract

Samples of mesoporous base-catalysed silica xerogel materials made by the sol-gel process were impregnated with an anticancer drug--doxorubicin, followed by different times of ageing at room temperature. The effect of ageing time on the physical and structural properties as well as sorption-desorption of the drug was investigated. The obtained results suggest an inverse relationship with a solid density and surface area increasing as the pore size and volume decrease during ageing time. These results also revealed the effect of ageing time on the efficiency of sorption-desorption of the drug. An increase in ageing time results in an increase of the efficiency of drug sorption and a decrease in the rate of drug release.

Stabilized Amorphous State of Ibuprofen by Co‐Spray Drying With Mesoporous SBA‐15 to Enhance Dissolution Properties

“…Therefore, it is desired to explore a new drug hosting system that can produce amorphous APIs with acceptable stability and shelf life. The discovery of a series of new ordered mesoporous silica material, which has a regular pore size distribution that can be systematically varied between 2 and 30 nm, has opened up new possibilities in pharmaceutical applications 14–17. Surface functionalized mesoporous MCM‐41 were investigated for controlled release of various APIs 18–20.…”

Adsorption of antitumor antibiotic doxorubicin on MCM-41-type silica surface

“…Adsorption of Dox was studied by Prokopowicz and coworkers on mesoporous xerogels with non-uniform pores (Prokopowicz and Przyjazny, 2007) as well as on mesoporous silica microparticles with ordered structure of uniform pores (Prokopowicz et al, 2016). It was found that interaction of positively charged doxorubicin hydrochloride with negatively charged silica centers (pH 6.6) leads to the drug adsorption on the surface of larger pores and its subsequent diffusion into the smaller ones.…”

“…In order to minimize undesired damages of healthy cells without reducing therapeutic action of Dox, drug carrier systems are widely used (Aznar et al, 2011;Bernardos et al, 2010;Chen et al, 2013;Gao et al, 2011;Gu et al, 2012;Hu et al, 2013;Knezevic et al, 2011Knezevic et al, , 2013Lee et al, 2010Lee et al, , 2011Maeda et al, 2003;Meng et al, 2010;Mishra et al, 2014;Nishiyama and Kataoka, 2003;Prokopowicz and Przyjazny, 2007;Prokopowicz et al, 2016;Safari and Zarnegar, 2014;Singh et al, 2011;Tan et al, 2011;Wang et al, 2011;Yang et al, 2008;Yokoyama, 2011;Yuan et al, 2011;Zhang et al, 2011). Among them, ordered mesoporous silicas of MCM-41 type are the most promising solid supports for the formation of biologically active systems (Aznar et al, 2011;Bernardos et al, 2010;Gu et al, 2012;Hu et al, 2013;Knezevic et al, 2011Knezevic et al, , 2013Lee et al, 2010Lee et al, , 2011Meng et al, 2010;Prokopowicz et al, 2016;Yuan et al, 2011).…”

Synthesis and Characterization of Novel pH-sensitive Nano Composites for Oral Drug Delivery

“…At the physiological buffer (pH around 7.4), the silanol groups (Si-OH) and -COOH in the nano carriers would become deprotonated, and a strong electrostatic repulsion between the negative charges of (SiO -and -COO -groups) and the negative charge of naproxen molecule would be generated. Consequently, the pH value of 7.4 promotes the release rate [16][17][18][19][20]. However, the residual drug molecules can be occluded in the channels which would restrict achieving achieve the overall release.…”