Synthesis of sodium alginate grafted stearate acid (NaAlg-g-St) and evaluation of the polymer as drug release controlling matrix

Chehardoli, Gholamabbas; Bagheri, Hanieh; Firozian, Farzin

doi:10.1007/s10965-019-1840-3

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…While only a few monomers of the polysaccharide are substituted with stearate groups, the esoteric peak is seen as a shoulder. This phenomenon has been observed in previous studies that have been conducted at the chemical modification of polysaccharides [29,[34][35][36].…”

Section: Resultssupporting

confidence: 77%

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Inulin-Grafted Stearate (In-g-St) as the Effective Self-Assembling Polymeric Micelle: Synthesis and Evaluation for the Delivery of Betamethasone

Chehardoli

Norouzian

Firozian

2020

Journal of Nanomaterials

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Background. Betamethasone as a corticosteroid drug is commonly used for the treatment of rheumatoid arthritis. Unfortunately, betamethasone is a low water-soluble drug and its efficacy is low. So an attractive strategy is the targeted delivery of betamethasone to the damaged joint using polymeric micelle-based carriers. Methods. Inulin-grafted stearate (In-g-St) was synthesized via the reaction of stearoyl chloride and inulin, then characterized by FT-IR and H-NMR. In-g-St forms micelles in the presence of betamethasone. The prepared polymeric micelles were characterized for size, zeta potential, drug loading, particles’ morphology, critical micelle concentration (CMC), and encapsulation efficiency. So sustained release polymeric micelles of betamethasone were developed by employing In-g-St. Results. The measurement of particle size showed a mean diameter of 60 and 130 nm for 10% and 20% drug-loaded micelles, respectively, and SEM showed that the particle’s morphologies are spherical. Zeta potential measurement for the drug-containing micelles showed a value of -11.8 mV. Drug loading efficiency and the encapsulation efficiency were 6.36% and 63.6%, as well as 18.97% and 94.88% for 10% and 20%, respectively. 20% drug-loaded polymer showed a small burst release of betamethasone at the first 3 h which was followed by sustained release in the next 24 h. Furthermore, the formula with 10% exhibited good sustained release properties except for the minor initial burst release. Conclusion. Data from the zeta potential, CMC, drug loading capacity, and in vitro drug release studies indicated that In-g-St polymeric micelles can be suitable candidates for the efficient delivery of hydrophobic drugs like betamethasone.

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Section: Resultssupporting

confidence: 77%

“…In continuation of our studies on the polymer manipulation [28] specially grafting [29], in the present study, inulin-grafted stearate (In-g-St) would be synthesized for the formation of polymeric micelles as suitable carriers of betamethasone. Also, the release profile of betamethasone from the polymeric micelles has been studied.…”

Section: Introductionmentioning

confidence: 99%

Inulin-Grafted Stearate (In-g-St) as the Effective Self-Assembling Polymeric Micelle: Synthesis and Evaluation for the Delivery of Betamethasone

Chehardoli

Norouzian

Firozian

2020

Journal of Nanomaterials

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“…So, positively charged micelles are a promising vehicle for the topical delivery of hydrophobic drugs for ocular penetration. 6,8 In continuation of our studies on the synthesis of polymeric micelles and their use in drug delivery, 9,10 in this study, we prepared indomethacin-loaded cationic micelles formed from the reaction of glycidyl trimethylammonium chloride (GTMAC) 11 and dextran stearate 12 to evaluate the ability of indomethacin penetration.…”

Section: ■ Introductionmentioning

confidence: 99%

Cationic Dextran Stearate (Dex-St-GTMAC): Synthesis and Evaluation as Polymeric Micelles for Indomethacin Corneal Penetration

Firozian,

Arabkhani,

Mahboobian

et al. 2023

ACS Omega

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Background Indomethacin as a non-steroidal anti-inflammatory drug (NSAID) is commonly used to treat some ocular inflammatory disorders. Unfortunately, indomethacin is a drug that is poorly soluble in water; therefore, it has low efficacy. An attractive approach is the targeted delivery of indomethacin to the cornea using cationic dextran stearate as a polymeric micelle drug carrier. Methods A dextran stearate-glycidyl trimethylammonium chloride (Dex-St-GTMAC) copolymer was prepared through the reaction of GTMAC, stearoyl chloride, and dextran. Then, Dex-St-GTMAC was characterized by Fourier transform infrared (FT-IR) spectroscopy and 1H NMR spectroscopy. Dex-St-GTMAC forms micelles in the presence of indomethacin. The prepared polymeric micelles were characterized for size, ζ-potential, drug loading, particle morphology, critical micelle concentration, and encapsulation efficiency. To study the irritation potential of the indomethacin-loaded Dex-St-GTMAC, Het-Cam and Draize tests have been performed. Prepared cationic micelles were subjected to the in vitro drug release and ex vivo trans-corneal permeation test. Results The dialysis method was used for the preparation of indomethacin-loaded micelles (10, 20, and 30%). Measurement of the particle size showed a mean diameter of 122.1 and 150.9 nm for the drug-loaded micelles. Scanning electron microscopy (SEM) images showed that the morphology of the particles is spherical. 10% formulation was chosen as the best formulation due to more surface charge and reasonable drug loading. ζ-potential measurement for the 10% drug-containing micelles showed a value of +39.1 mV. Drug loading efficiency and the encapsulation efficiency for 10% drug-containing micelles were 6.36 and 63.61%, respectively. The results of the Het-Cam and Draize tests indicated that the indomethacin-loaded Dex-St-GTMAC formulation had no toxicity to eye tissues. Based on our results, the prepared micelles (indomethacin-loaded Dex-St-GTMAC) exhibited a sustained drug release pattern compared to the control group. Indomethacin penetration from the micelles to the excised bovine cornea was 1.75-fold greater than the control (indomethacin 0.1% in phosphate-buffered saline (PBS)). Conclusions Data from the ζ-potential, SEM, drug loading capacity, and in vitro drug release studies indicated that cationic dextran stearate polymeric micelles are an appropriate carrier for the efficient penetration of indomethacin into cornea tissues.

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Innovative environment-friendly liquid fertilizer bead from sodium alginate coating with IPN membrane derived from natural rubber and cassava starch

Phansroy,

Boonyod,

Mulasake

et al. 2024

J Polym Res

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This research aims to prepare liquid fertilizer beads formed with sodium alginate (SA) (SAB) that were coated with interpenetrating polymer network (IPN) hydrogels based on pre-vulcanized natural rubber latex (NR) and cassava starch (St) (IPN NR/St) for controlling the release of the urea solutions. The preparation of SAB at various concentrations of SA and calcium chloride (CaCl 2 ) solutions was investigated. It was found that the appropriate concentrations of SA and CaCl 2 solutions were 1.5 and 5.0 wt%, respectively. The obtained SAB was coated with IPN NR/St, the ratio between SAB and IPN NR/St at 1.0/1.0, and the number of coated layers of IPN NR/St at 2 layers. As a result, coated alginate beads (CSAB) can decelerate the release of urea solution, and enhance the Thai eggplant growth. Thus, the CSAB could enhance not only the release control of urea solution but also lesser environmental problems, and is a novel technique for coating and the liquid release control for organic or biofertilizers.

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Synthesis of sodium alginate grafted stearate acid (NaAlg-g-St) and evaluation of the polymer as drug release controlling matrix

Cited by 8 publications

References 26 publications

Inulin-Grafted Stearate (In-g-St) as the Effective Self-Assembling Polymeric Micelle: Synthesis and Evaluation for the Delivery of Betamethasone

Inulin-Grafted Stearate (In-g-St) as the Effective Self-Assembling Polymeric Micelle: Synthesis and Evaluation for the Delivery of Betamethasone

Cationic Dextran Stearate (Dex-St-GTMAC): Synthesis and Evaluation as Polymeric Micelles for Indomethacin Corneal Penetration

Innovative environment-friendly liquid fertilizer bead from sodium alginate coating with IPN membrane derived from natural rubber and cassava starch

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