A novel Pd-catalyzed three-component domino reaction
for the stereoselective
synthesis of highly functionalized allyl cinnamates has been developed.
In this protocol, a sequential process of C–C bond activation
and intermolecular allylic substitution was well-organized. The key
for this transformation is the in situ generated
hydrolysis product of cyclopropenone, which triggered a new reaction
with vinylethylene carbonates. The reaction mechanism was investigated,
demonstrating the high stereoselectivity and excellent atomic economy
in this process.