Synthesis of silver nanoparticles using the Streptomyces coelicolor klmp33 pigment: An antimicrobial agent against extended-spectrum beta-lactamase (ESBL) producing Escherichia coli
“…Nanotechnology is a rapidly growing field with potential application in fields ranging from electronics to cosmetics [1,2]. Nanoscience covers the basic understanding of physical, chemical and biological properties in atomic and sub-atomic levels [3].…”
“…Nanotechnology is a rapidly growing field with potential application in fields ranging from electronics to cosmetics [1,2]. Nanoscience covers the basic understanding of physical, chemical and biological properties in atomic and sub-atomic levels [3].…”
“…In the United States alone, roughly 1.7 million estimated nosocomial infections, primarily from bacteria and fungi, are responsible for 99,000 deaths each year (Klevens et al, 2007). Owing to this increased resistance of several pathogenic bacteria against antibiotics, considerable attention has been focused on developing new treatment modalities featuring alternative antibacterial agents (Aziz et al, 2014; Manikprabhu and Lingappa, 2014; Teillant et al, 2015). In this milieu, metallic silver, especially in the form of nanoparticle and nanostructured substrates, has received considerable traction for antibacterial activity due to its unique physiochemical properties (Husain et al, 2015; Prasad et al, 2016).…”
Driven by the need to engineer robust surface coatings for medical devices to prevent infection and sepsis, incorporation of nanoparticles has surfaced as a promising avenue to enhance non-fouling efficacy. Microbial synthesis of such nanoscale metallic structures is of substantive interest as this can offer an eco-friendly, cost-effective, and sustainable route for further development. Here we present a Mucor hiemalis-derived fungal route for synthesis of silver nanoparticles, which display significant antimicrobial properties when tested against six pathological bacterial strains (Klebsiella pneumoniae, Pseudomonas brassicacearum, Aeromonas hydrophila, Escherichia coli, Bacillus cereus, and Staphylococcus aureus) and three pathological fungal strains (Candida albicans, Fusarium oxysporum, and Aspergillus flavus). These antimicrobial attributes were comparable to those of established antibiotics (streptomycin, tetracycline, kanamycin, and rifampicin) and fungicides (amphotericin B, fluconazole, and ketoconazole), respectively. Importantly, these nanoparticles show significant synergistic characteristics when combined with the antibiotics and fungicides to offer substantially greater resistance to microbial growth. The blend of antibacterial and antifungal properties, coupled with their intrinsic “green” and facile synthesis, makes these biogenic nanoparticles particularly attractive for future applications in nanomedicine ranging from topical ointments and bandages for wound healing to coated stents.
“…A yield of approximately 0.17 g /100 mL was obtained from the synthetic process and used for further study. Manikprabhu and Lingappa [4] previously reported the synthesis of silver nanoparticles using Streptomyces coeliolor KLMP33 pigment with a yield of 0.14 g / 100 mL. Flexirubins are a unique type of bacterial pigment, used in the treatment of chronic skin diseases, eczema, and gastric ulcers, etc.…”
Section: Synthesis and Characterization Of Silver Nanoparticlesmentioning
confidence: 99%
“…Among diverse metals, silver in its various forms has been widely used as a medicine for the treatment of a spectrum of diseases since ancient times [4]. Also known for its inhibitory effects on microbes in both medical treatments and industrial processes [5], the anti-microbial properties of silver are intensified following its transformation into a nanoparticle, rendering it useful in effectively eliminating fungus and bacteria [6].…”
Section: Introductionmentioning
confidence: 99%
“…As a natural material, silver is considered safe to man and produces few allergic reactions during clinical testing [7]. Silver nanoparticles have garnered attention due to their applicability in diverse areas such as catalysis, nanomedicine, biological labelling, solar cell surfaces, as staining pigments for glasses and ceramics, and as antimicrobial agents [4]. Apart from their antimicrobial properties, silver nanoparticles have been shown to have potential as anticancer agents due to their selective role in disrupting the mitochondrial respiratory chain which leads to the production of reactive oxygen species (ROS) and interruption of adenosine triphosphate (ATP) synthesis, thus causing nucleic acid damage [8,9].…”
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