Synthesis of silver nanoparticles using gallic acid-conjugated chitosan derivatives

Lunkov, Alexey; Shagdarova, Balzhima; Konovalova, M. V.; Zhuikova, Yuliya; Дрозд, Н. Н.; Ильина, А. В.; Варламов, В. П.

doi:10.1016/j.carbpol.2020.115916

Cited by 42 publications

(19 citation statements)

References 34 publications

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“…However, the main disadvantage of such nanoparticles is cytotoxicity [ 44 ]. To improve the biocompatibility of AgNPs, in our earlier study we synthesized AgNPs using quaternized chitosan with gallic acid [ 34 ]. The synthesized NPs were positively charged, the ζ-potential of the particles was 29 mV, their size was 13 and 45.9 nm as estimated by TEM and DLS, respectively (see Supplementary Materials ).…”

Section: Resultsmentioning

confidence: 99%

“…Silver nanoparticles were obtained using quaternized chitosan with gallic acid (NPs) as a stabilizing and reducing agent as described in [ 34 ]. Quaternized chitosan was obtained using glycidyltrimethylammonium chloride according to the method [ 35 ], then using carbodiimide and N-hydroxysuccinimide, gallic acid was cross linked to the chitosan derivative, obtaining quaternized chitosan with gallic acid (QCG) according to the method [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

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Collagen/Chitosan Gels Cross-Linked with Genipin for Wound Healing in Mice with Induced Diabetes

et al. 2021

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Diabetes mellitus continues to be one of the most common diseases often associated with diabetic ulcers. Chitosan is an attractive biopolymer for wound healing due to its biodegradability, biocompatibility, mucoadhesiveness, low toxicity, and hemostatic effect. A panel of hydrogels based on chitosan, collagen, and silver nanoparticels were produced to treat diabetic wounds. The antibacterial activity, cytotoxicity, swelling, rheological properties, and longitudinal sections of hydrogels were studied. The ability of the gels for wound healing was studied in CD1 mice with alloxan-induced diabetes. Application of the gels resulted in an increase in VEGF, TGF-b1, IL-1b, and TIMP1 gene expression and earlier wound closure in a comparison with control untreated wounds. All gels increased collagen deposition, hair follicle repair, and sebaceous glands formation. The results of these tests show that the obtained hydrogels have good mechanical properties and biological activity and have potential applications in the field of wound healing. However, clinical studies are required to compare the efficacy of the gels as animal models do not reproduce full diabetes pathology.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Collagen/Chitosan Gels Cross-Linked with Genipin for Wound Healing in Mice with Induced Diabetes

et al. 2021

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“…S. acuta IR spectra exhibited free O-H stretching groups at 3728 cm −1 , 3609 cm −1 , and 948 cm −1 , C-H vibrations near 2988 cm −1 , 2884 cm −1 , 2361 cm −1 , 1391 cm −1 and 676 cm −1 , N-H bands around 1663 cm −1 , 1552 cm −1 , and C-Br vibrations near 575 cm −1 , 530 cm −1 and 467 cm −1 assigned to the carboxylic, phenolic and amine functional groups present in leaf extract [39,40]. CS FTIR spectra showed a typical amine stretches near 1656 cm −1 and 1395 cm −1 , hydroxyl bands at 3633 cm −1 , 669 cm −1 , and 624 cm −1 , C-C and C=O vibrations around 1552 cm −1 , 941 cm −1 , and 903 cm −1 , and C-H bands near 844 cm −1 , 572 cm −1 and 460 cm −1 were attributed to the amine groups and acetylated groups of CS [41,42]. CS/FeO NC IR spectra revealed the presence of O-H bands around 1080 cm −1 , and 958 cm −1 , C-H bands at 2976 cm −1 , 2889 cm −1 , 1255 cm −1 and 1150 cm −1 , N-H and C=O bands at 1384 cm −1 , Fe-O bands at 689 cm −1 , 644 cm −1 , 546 cm −1 , 487 cm −1 , 410 cm −1 [43].…”

Section: Ftir Analysismentioning

confidence: 99%

Biogenic Preparation, Characterization, and Biomedical Applications of Chitosan Functionalized Iron Oxide Nanocomposite

et al. 2022

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Chitosan (CS) functionalization over nanomaterials has gained more attention in the biomedical field due to their biocompatibility, biodegradability, and enhanced properties. In the present study, CS functionalized iron (II) oxide nanocomposite (CS/FeO NC) was prepared using Sida acuta leaf extract by a facile and eco-friendly green chemistry route. Phyto-compounds of S. acuta leaf were used as a reductant to prepare CS/FeO NC. The existence of CS and FeO crystalline peaks in CS/FeO NC was confirmed by XRD. FE-SEM analysis revealed that the prepared CS/FeO NC were spherical with a 10–100 nm average size. FTIR analyzed the existence of CS and metal-oxygen bands in the prepared NC. The CS/FeO NC showed the potential bactericidal activity against E. coli, B. subtilis, and S. aureus pathogens. Further, CS/FeO NC also exhibited the dose-dependent anti-proliferative property against human lung cancer cells (A549). Thus, the obtained outcomes revealed that the prepared CS/FeO NC could be a promising candidate in the biomedical sector to inhibit the growth of bacterial pathogens and lung cancer cells.

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“…Gallic acid, being an environmentally friendly "green" reagent, is also relatively cheap. Moreover, gallic acid exhibits a broad spectrum of activity when it comes to reducing various metal precursors, which allows it to be used in the synthesis of numerous monometallic NPs as well as multicomponent nanocomplexes [25][26][27][28][29]. By controlling the reaction parameters (e.g., temperature or polyvinylpyrrolidone addition), it is possible to obtain nanoparticles with various sizes [30].…”

Section: Mechanism Of Aupt Ncs (Gold-platinum Nanocauliflowers) Synthmentioning

confidence: 99%

Fancy-Shaped Gold–Platinum Nanocauliflowers for Improved Proton Irradiation Effect on Colon Cancer Cells

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et al. 2020

IJMS

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Enhancing the effectiveness of colorectal cancer treatment is highly desirable. Radiation-based anticancer therapy—such as proton therapy (PT)—can be used to shrink tumors before subsequent surgical intervention; therefore, improving the effectiveness of this treatment is crucial. The addition of noble metal nanoparticles (NPs), acting as radiosensitizers, increases the PT therapeutic effect. Thus, in this paper, the effect of novel, gold–platinum nanocauliflowers (AuPt NCs) on PT efficiency is determined. For this purpose, crystalline, 66-nm fancy shaped, bimetallic AuPt NCs were synthesized using green chemistry method. Then, physicochemical characterization of the obtained AuPt NCs by transmission electron microscopy (TEM), selected area electron diffraction (SAED), energy dispersive X-ray spectroscopy (EDS), and UV-Vis spectra measurements was carried out. Fully characterized AuPt NCs were placed into a cell culture of colon cancer cell lines (HCT116, SW480, and SW620) and a normal colon cell line (FHC) and subsequently subjected to proton irradiation with a total dose of 15 Gy. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) test, performed after 18-h incubation of the irradiated cell culture with AuPt NCs, showed a significant reduction in cancer cell viability compared to normal cells. Thus, the radio-enhancing features of AuPt NCs indicate their potential application for the improvement in effectiveness of anticancer proton therapy.

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Synthesis of silver nanoparticles using gallic acid-conjugated chitosan derivatives

Cited by 42 publications

References 34 publications

Collagen/Chitosan Gels Cross-Linked with Genipin for Wound Healing in Mice with Induced Diabetes

Collagen/Chitosan Gels Cross-Linked with Genipin for Wound Healing in Mice with Induced Diabetes

Biogenic Preparation, Characterization, and Biomedical Applications of Chitosan Functionalized Iron Oxide Nanocomposite

Fancy-Shaped Gold–Platinum Nanocauliflowers for Improved Proton Irradiation Effect on Colon Cancer Cells

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