Synthesis of silver nanoparticles from secondary metabolites of star gooseberry fruit (Phyllanthus acidus) and their nephroprotective efficiency

Banerjee, Swarnendra; Kar, Pallab; Islam, Rejuan; Naidoo, Devashan; Roy, Ayan; Sarkar, Indrani; Sen, Gargi; Saha, Tilak; Yasmin, Hadida; Sen, Arnab

doi:10.1016/j.sajb.2022.10.021

Cited by 3 publications

(2 citation statements)

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“…The Bcl-X L protein exhibited positive molecular docking interactions with silver nanoparticles derived from Elaeagnus pyriformis , with binding energies of −6.8 kcal/mol and −6.5 kcal/mol, respectively [ 148 ]. Banerjee et al [ 149 ] synthesized silver nanoparticles in a different work using fruit extract from Phyllanthus acidus . The produced nanoparticles had an inhibitory effect on the inflammatory protein NFκβ, according to an in silico molecular docking analysis, with docking scores of −6.9 and −6.5 Kcal/mol [ 149 ].…”

Section: Analysis Of Biomacromolecule–np Interactions Using Molecular...mentioning

confidence: 99%

“…Banerjee et al [ 149 ] synthesized silver nanoparticles in a different work using fruit extract from Phyllanthus acidus . The produced nanoparticles had an inhibitory effect on the inflammatory protein NFκβ, according to an in silico molecular docking analysis, with docking scores of −6.9 and −6.5 Kcal/mol [ 149 ]. Among the six different isoforms of cytochrome P450 (CYP), Ag NPs have been demonstrated to bind with great affinity to CYP2C9, CYP2C19, and CYP2D6 in the human body [ 150 ].…”

Section: Analysis Of Biomacromolecule–np Interactions Using Molecular...mentioning

confidence: 99%

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Molecular Docking Approach for Biological Interaction of Green Synthesized Nanoparticles

Kar,

Oriola,

Oyedeji

2024

Molecules

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In recent years, significant progress has been made in the subject of nanotechnology, with a range of methods developed to synthesize precise-sized and shaped nanoparticles according to particular requirements. Often, the nanoparticles are created by employing dangerous reducing chemicals to reduce metal ions into uncharged nanoparticles. Green synthesis or biological approaches have been used recently to circumvent this issue because biological techniques are simple, inexpensive, safe, clean, and extremely productive. Nowadays, much research is being conducted on how different kinds of nanoparticles connect to proteins and nucleic acids using molecular docking models. Therefore, this review discusses the most recent advancements in molecular docking capacity to predict the interactions between various nanoparticles (NPs), such as ZnO, CuO, Ag, Au, and Fe3O4, and biological macromolecules.

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Section: Analysis Of Biomacromolecule–np Interactions Using Molecular...mentioning

confidence: 99%

Section: Analysis Of Biomacromolecule–np Interactions Using Molecular...mentioning

confidence: 99%

Molecular Docking Approach for Biological Interaction of Green Synthesized Nanoparticles

Kar,

Oriola,

Oyedeji

2024

Molecules

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Bio-based synthesis of silver nanoparticles using leaf extract of Uraria picta (Jacq.) Desv. ex DC.: Characterization and evaluation of its activity against Leishmania donovani

Dixit,

Kumar,

Singh

et al. 2024

Biomass Conv. Bioref.

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Turmeric–Black Cumin Essential Oils and Their Capacity to Attenuate Free Radicals, Protein Denaturation, and Cancer Proliferation

Oriola

2024

Molecules

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Turmeric rhizomes (Curcuma longa) and black cumin seeds (Nigella sativa) are polyherbal ingredients used for the management of cancer and other chronic inflammatory diseases in Nigerian ethnomedicine. Previous studies have shown the antioxidant, anti-inflammatory, and anticancer activities of the individual plant extracts. However, the two spices have not been biologically potentiated in their combined form. Therefore, this study obtained essential oils (EOs) from the combined spices and evaluated their inhibitory effects on free radicals, protein denaturation, and cancer proliferation. The EOs were extracted by hydro-distillation (HD) and characterized by gas chromatography-mass spectrometry (GC-MS). In vitro antioxidant assessment was conducted based on DPPH, hydrogen peroxide (H2O2), nitric oxide (NO), and ferric ion (Fe3+) radical scavenging assays. The cytotoxicity of the oil against non-tumorigenic (HEK293) and cancerous (HepG2 and HeLa) cell lines was determined following the MTT cell viability assay. An in silico molecular docking analysis of the oil constituents was also performed. Six batches of EOs I–VI were afforded, comprising twenty-two major constituents, with aromatic Ar-turmerone being the most prominent compound. There was a marked improvement in the bioactivity of the oils upon repeated HD and as a combination. The batch VI oil exhibited the best activity, with a cytotoxicity (CC50) of 10.16 ± 1.69 µg/100 µL against the HepG2 cell line, which was comparable to 5-fluorouracil (standard, CC50 = 8.59 ± 1.33 µg/100 µL). In silico molecular docking suggested δ-curcumene, Ar-curcumene, Ar-turmerol, and Ar-turmerone among the promising compounds based on their high binding energy scores with NOX2, NF-κB, and mdm2 proteins. In conclusion, the oils from the turmeric–black cumin combined possess a considerable inhibition ability against free radicals, protein denaturation, and cancer proliferation. This study’s findings further underscore the effectiveness of turmeric–black cumin as a polyherbal medicinal ingredient.

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Synthesis of silver nanoparticles from secondary metabolites of star gooseberry fruit (Phyllanthus acidus) and their nephroprotective efficiency

Cited by 3 publications

References 49 publications

Molecular Docking Approach for Biological Interaction of Green Synthesized Nanoparticles

Molecular Docking Approach for Biological Interaction of Green Synthesized Nanoparticles

Bio-based synthesis of silver nanoparticles using leaf extract of Uraria picta (Jacq.) Desv. ex DC.: Characterization and evaluation of its activity against Leishmania donovani

Turmeric–Black Cumin Essential Oils and Their Capacity to Attenuate Free Radicals, Protein Denaturation, and Cancer Proliferation

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