Synthesis of silica nanoparticles for biological applications

Shukur, Ali; Farooq, Asima; Whitehead, Debra; Azzawi, May

doi:10.1016/b978-0-12-820757-4.00014-4

Cited by 4 publications

(3 citation statements)

References 183 publications

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“…The internal structure of NPS can be porous or non-porous, depending on the desired application. Their main advantage is the ability to combine diagnostics and therapy by being able to function as contrast agents and therapy delivery simultaneously [257,258].…”

Section: Bionanomaterialsmentioning

confidence: 99%

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Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers

Larrea,

Elexpe,

Díez-Martín

et al. 2023

CIMB

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Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity and motor dysfunction by affecting the neuronal connection responsible for motor control. The diagnosis of this pathology is performed using neuroimaging techniques and molecular diagnostics based on identifying and measuring signaling molecules or specific markers. In parallel, new therapeutic targets are being investigated via the use of bionanomaterials and electrostimulation to modulate the neuroinflammatory response. These novel diagnostic and therapeutic strategies have the potential to facilitate the development of anticipatory patterns and deliver the most beneficial treatment to improve patients’ quality of life and directly impact their motor skills. However, important challenges remain to be solved. Hence, the goal of this study was to review the implication of neuroinflammation in the evolution of motor function in stroke and trauma patients, with a particular focus on novel methods and potential biomarkers to aid clinicians in diagnosis, treatment, and therapy. A specific analysis of the strengths, weaknesses, threats, and opportunities was conducted, highlighting the key challenges to be faced in the coming years.

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Section: Bionanomaterialsmentioning

confidence: 99%

“…o Silica nanoparticles with imaging agents: Incorporate fluor surfactants or contrast agents for MRI [261]. o Multifunctional silica nanoparticles: Combine several features [257].…”

Section: Bionanomaterialsmentioning

confidence: 99%

Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers

Larrea,

Elexpe,

Díez-Martín

et al. 2023

CIMB

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show abstract

“…SNPs have drawn extensive attention due to their applications in many emerging areas significantly in applied chemistry fields, as they have tailorable morphology (Twaffiek & Elhadad, 2020), in agriculture, foods, and drug delivery (Ranjha et al, 2022). For example, thiol‐modified silica nanoparticles have been used for the preconcentration of drugs and pesticide (Shukur et al, 2022). Gold‐coated silica nanoparticles have been described for the analysis of mercury in natural waters (Pawliszyn, 2012).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of silica nanoparticles as an efficient carrier for two bio‐detergents based enzymes

Salamony

Gayar

Mahdy

et al. 2023

J Surfact & Detergents

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Bio-detergents are new bio-friendly formulas that contain biobased ingredients, including enzymes. In the present study, alkaline protease and α-amylase were immobilized via physisorption onto silica nanoparticles (SNPs). The derivatized SNPs served as major components of a prepared bio-detergent. Alkaline protease was produced by the recombinant Bacillus subtilis cells that carry the protease genes on a multiple-copy plasmid, while α-amylase was commercially purchased. SNPs were prepared by the sol-gel method and well-characterized through the Brunauer-Emmett-Teller (BET) method, scanning electron microscopy (SEM), transmission electron microscopy (TEM), zeta potential, X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. The adsorption capacity of the SNPs was determined via colorimetry through the adsorption of methylene blue dye (MB), with approximately 97% adsorption achieved under the conditions employed. The Langmuir isotherm welldescribed the adsorption of MB on SNPs. High immobilization yield for the enzymes was obtained, and the storage stability of SNP-alkaline protease and SNP-α-amylase was good, reaching 65% and 85% of their initial activities after 6 weeks of storage at 4 C, respectively. The immobilized enzymes could be reused for 7 cycles. Additionally, the immobilized enzymes retained residual activity to a greater extent than free enzymes in simulated basic detergent solutions. SNPs containing adsorbed alkaline protease and α-amylase were mixed with a basic detergent solution, and the washing efficiency of some proteinous and starchy stains was examined through Hunter Lab spectrophotometry. The latter experiments demonstrated that the immobilized enzymes performed well during the washing process.

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Thermal degradation of non-isocyanate polyurethanes

Bukowczan,

Łukaszewska,

Pielichowski

2024

J Therm Anal Calorim

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Non-isocyanate polyurethanes (NIPUs) are considered as a class of environmentally-safe polymers that show promising properties, such as chemical and mechanical resistance. An important feature that may limit some important applications is the thermal degradation behavior of NIPUs and their composites and hybrids. Hence, this article comprehensively reviews recent developments in these materials groups, focusing on the thermal stability and degradation routes. Influence of urethane linkage vicinity, molar mass and ratio of carbonate and amine components, and chemical structure on NIPU thermal degradation behavior was discussed. The onset temperature of degradation was found to be mainly influenced by urethane bonds concentration and crosslinking density of NIPU material. Chain length of amine component has also a significant impact on the thermal degradation profile. The incorporation of bio-sourced and nano-scaled additives (carbon- and silica-based nanoparticles) and their impact on thermal stability of NIPU matrix was analyzed, too, and future outlooks were given.

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Synthesis of silica nanoparticles for biological applications

Cited by 4 publications

References 183 publications

Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers

Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers

Preparation and characterization of silica nanoparticles as an efficient carrier for two bio‐detergents based enzymes

Thermal degradation of non-isocyanate polyurethanes

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