Synthesis of short graphene oxide nanoribbons for improved biomarker detection of Parkinson's disease

Sun, Chia‐Liang; Su, Chih-Chiang; Wu, Jhing-Jhou

doi:10.1016/j.bios.2014.08.046

Cited by 31 publications

(27 citation statements)

References 50 publications

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“…Such inactive edges decrease the effective channel width of the nanoribbon FETs and hence are a major disadvantage for achieving low detection limits [5]. This may be primarily attributed to the presence of active chemical oxygen groups required for thiol functionalization near the edges, which if they cannot contribute towards the effective channel conductance, a significant number of immobilized biomolecules become redundant, suppressing the overall sensitivity [6]. Chemically derived GNRs can circumvent this problem since they have ultra-smooth edges [7,8,9], but as they are dispersed in solution, it requires dip coating or spinning to transfer them to silicon oxide substrates, resulting in totally random orientations of the GNRs.…”

Section: Introductionmentioning

confidence: 99%

Graphene Nanogrids FET Immunosensor: Signal to Noise Ratio Enhancement

Basu

RoyChaudhuri

2016

Sensors

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Recently, a reproducible and scalable chemical method for fabrication of smooth graphene nanogrids has been reported which addresses the challenges of graphene nanoribbons (GNR). These nanogrids have been found to be capable of attomolar detection of biomolecules in field effect transistor (FET) mode. However, for detection of sub-femtomolar concentrations of target molecule in complex mixtures with reasonable accuracy, it is not sufficient to only explore the steady state sensitivities, but is also necessary to investigate the flicker noise which dominates at frequencies below 100 kHz. This low frequency noise is dependent on the exposure time of the graphene layer in the buffer solution and concentration of charged impurities at the surface. In this paper, the functionalization strategy of graphene nanogrids has been optimized with respect to concentration and incubation time of the cross linker for an enhancement in signal to noise ratio (SNR). It has been interestingly observed that as the sensitivity and noise power change at different rates with the functionalization parameters, SNR does not vary monotonically but is maximum corresponding to a particular parameter. The optimized parameter has improved the SNR by 50% which has enabled a detection of 0.05 fM Hep-B virus molecules with a sensitivity of around 30% and a standard deviation within 3%. Further, the SNR enhancement has resulted in improvement of quantification accuracy by five times and selectivity by two orders of magnitude.

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Section: Introductionmentioning

confidence: 99%

Graphene Nanogrids FET Immunosensor: Signal to Noise Ratio Enhancement

Basu

RoyChaudhuri

2016

Sensors

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“…12 This meant a core−shell MWCNT/GONR heterostructure would more likely appear instead of the fully unzipped nanoribbon structure through all microwave powers in the new process. To compare with the short GONR in our previous studies, 34 the higher microwave power generated more notches on the side of the ribbons and did not form nice, smooth ribbon edges. Note that we used two different kinds of Cu grids in Figure 1a.…”

Section: Resultsmentioning

confidence: 86%

“…X-ray photoelectron spectroscopy (XPS, Kratos Axis Ultra DLD) measurements were also carried out for determining the compositional analysis. 12, 34 3.13. Statistical Analysis.…”

Section: Experimental Materials and Methodsmentioning

confidence: 99%

Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism

et al. 2020

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In the melanin synthesis process, oxidative reactions play an essential role, and it is a good strategy to inhibit melanin production by reducing oxidative stress. Fullerene and its derivatives, or the complexes, were considered as strong freeradical scavengers, and we further applied multilayered sp 2 nanocarbons to discover melanin synthesis inhibitory mechanisms. In the present study, we used novel nanomaterials, such as multiwalled carbon nanotubes (MWCNTs), short-type MWCNTs, graphene oxide nanoribbons (GONRs), and short-type GONRs, as anti-oxidative agents to regulate melanin production. The results showed that GONRs had better anti-oxidative capabilities in intracellular and extracellular oxidative stress analysis platforms than others. We proposed that GONRs have oxygen-containing functional groups. In the 2′,7′-dichlorodihydrofluorescein diacetate assay, we found out GONR could chelate metal ions to scavenge reactive oxygen species. In the molecular insight view, we observed that these nanomaterials downregulated the melanin synthesis by decreasing microphthalmia-associated transcription factor-related gene expressions, and there were similar consequences in protein expressions. To sum up, GONRs is a potential agent as a novel antioxidant and skin-whitening cosmetology material.

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“…In addition, techniques for detection of UA are growing more efficient. Using the novel short graphene oxide nanoribbons (GONRs), which provide improved electrochemical signals at the same concentrations of analytes and test conditions, the minimum detection limits of UA could reach 98 nM [38].…”

Section: ↑[14]mentioning

confidence: 99%

Recent advances in biomarkers for Parkinson’s disease focusing on biochemicals, omics and neuroimaging

Ren¹,

Sun²,

Zhao³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:Parkinson's disease (PD) is one of the most common neurodegenerative disorders, involving progressive loss of the nigro-striatal dopaminergic neurons. Cardinal symptoms including tremors, muscle rigidity, drooping posture, drooping, walking difficulty, and autonomic symptoms appear when a significant number of nigrostriatal dopaminergic neurons have already been destroyed. Hence, reliable biomarkers are needed for early and accurate diagnosis to measure disease progression and response to therapy. We review the current status of protein and small molecule biomarkers involved in oxidative stress, protein aggregation and inflammation etc. which are present in cerebrospinal fluid, human blood, urine or saliva. In recent years, advances in genomics, proteomics, metabolomics, and functional brain imaging techniques have led to new insights into the pathoetiology of PD. Further studies in the novel discovery of PD biomarkers will provide avenues to treat PD patients more effectively with few or no side effects.

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Synthesis of short graphene oxide nanoribbons for improved biomarker detection of Parkinson's disease

Cited by 31 publications

References 50 publications

Graphene Nanogrids FET Immunosensor: Signal to Noise Ratio Enhancement

Graphene Nanogrids FET Immunosensor: Signal to Noise Ratio Enhancement

Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism

Recent advances in biomarkers for Parkinson’s disease focusing on biochemicals, omics and neuroimaging

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