Synthesis of SERS-active core–satellite nanoparticles using heterobifunctional PEG linkers

Juan, Angela Michelle T. San; Chavva, Suhash Reddy; Tu, Dandan; Tircuit, Melanie; Coté, Gerard L.; Mabbott, Samuel

doi:10.1039/d1na00676b

Cited by 13 publications

(5 citation statements)

References 64 publications

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“…Therefore, materials that have affinities with metal nanoparticles have been the main targets of detection in related research. [26][27][28] However, most neurotransmitters, including the aforementioned neurotransmitters, have less affinities with metal nanoparticles. 29,30 So, to detect neurotransmitters using SERS, it is necessary to design a method that can attract them close to the surface of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

SERS detection of dopamine using metal-chelated Ag nanoshell

Kim,

Choi,

Jeong

2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

SERS detection of dopamine using metal-chelated Ag nanoshell

Kim,

Choi,

Jeong

2024

RSC Adv.

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“…2,19 SERS methods utilize the significant Raman scattering amplification afforded by the close association of Raman-active dyes or biomarkers with plasmonic metal nanostructures to detect targets of interest sensitively and specifically. [20][21][22][23][24] SERS-active substrates have been developed for inclusion in diagnostic platforms that may be suitable for POC applications, including paper and microfluidic cartridges. 20 Furthermore, the narrow bandwidths of Raman peaks make the technique an ideal candidate for multiplexed detection due to the ability to resolve multiple peaks of interest within a complex matrix.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Clinical Utility of Raman Spectroscopy for Point-of-Care Cardiovascular Disease Biomarker Detection

Soliman

Mabbott

et al. 2023

Appl Spectrosc

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A variety of innovative point-of-care (POC) solutions using Raman systems have been explored. However, the vast effort is in assay development, while studies of the characteristics required for Raman spectrometers to function in POC applications are lacking. In this study, we tested and compared the performance of eight commercial Raman spectrometers ranging in size from benchtop Raman microscopes to portable and handheld Raman spectrometers using paper fluidic cartridges, including their ability to detect cardiac troponin I and heart fatty acid binding protein, both of which are well-established biomarkers for evaluating cardiovascular health. Each spectrometer was evaluated in terms of excitation wavelength, laser characteristics, and ease of use to investigate POC utility. We found that the Raman spectrometers equipped with 780 and 785 nm laser sources exhibited a reduced background signal and provided higher sensitivity compared to those with 633 and 638 nm laser sources. Furthermore, the spectrometer equipped with the single acquisition line readout functionality showed improved performance when compared to the point scan spectrometers and allowed measurements to be made faster and easier. The portable and handheld spectrometers also showed similar detection sensitivity to the gold standard instrument. Lastly, we reduced the laser power for the spectrometer with single acquisition line readout capability to explore the system performance at a laser power that change the classification from a Class 3B laser device to a Class 3R device and found that it showed comparable performance. Overall, these findings show that portable Raman spectrometers have the potential to be used in POC settings with accuracy comparable to laboratory-grade instruments, are relatively low-cost, provide fast signal readout, are easy to use, and can facilitate access for underserved communities.

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“…Gold nanoparticles (Au-NPs) are employed as enhancers in SERS due to the surface plasmon resonance, which involves collective oscillations of surface electrons of NPs. During the optimization of the performance of NP-based Raman enhancers, reports have shown that the size, − shape, − and interparticle distance , play a crucial role. However, a detailed correlation between the structure of Au-NP monolayers and their performance as SERS substrates is still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Influence of Gold Nanoparticle Assembly in Langmuir–Schaefer Monolayers on the Surface-Enhanced Spectroscopy Response of a Nanoplatform

et al. 2023

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Gold nanoparticles (Au-NPs) are among the most commonly used materials for increasing the sensitivity of Raman spectroscopy. This is mainly due to the strong and tunable surface plasmon resonances, which can be easily adjusted by choosing the shape and size of individual NPs. However, recent findings indicate that controlling the density of NPs in their assemblies is an equally important parameter. An efficient way to achieve such control is by using the Langmuir–Schaefer technique, which yields single-layer assemblies of NPs on a solid substrate. In this study, we correlate the density and thermodynamic properties of a monolayer of spherical Au-NPs with their performance as Raman substrates. Hence, hydrophobic NPs were synthesized and assembled into films using the Langmuir–Schaefer technique. The surface-enhanced Raman spectroscopy (SERS) showed various degrees of enhancement depending on the different ranges of transfer surface pressures employed, which almost doubled the expected SERS signal intensity at the highest deposition surface pressure. To gain greater insights into this phenomenon, we investigated the NP distribution in the Langmuir and Langmuir–Schaefer films by detailed spectroscopic and electron and optical microscopic analyses. A correlation was observed between NP enhancements on the micro- and nanoscale. The presented results demonstrated the potential of adjusting the Raman responses in ultrasensitive detection by controlling the thermodynamic properties of NP monolayers.

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Synthesis of SERS-active core–satellite nanoparticles using heterobifunctional PEG linkers

Abstract: Here we report the synthesis of core–satellite nanoparticles to explore tunable SERS hot-spot generation, signal reproducibility and long-term activity.

Cited by 13 publications

References 64 publications

SERS detection of dopamine using metal-chelated Ag nanoshell

SERS detection of dopamine using metal-chelated Ag nanoshell

Exploring the Clinical Utility of Raman Spectroscopy for Point-of-Care Cardiovascular Disease Biomarker Detection

Influence of Gold Nanoparticle Assembly in Langmuir–Schaefer Monolayers on the Surface-Enhanced Spectroscopy Response of a Nanoplatform

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