Synthesis of site‐specific Fab‐drug conjugates using ADP‐ribosyl cyclases
Hyo Sun Kim,
Kimia Hariri,
Xiao‐Nan Zhang
et al.
Abstract:Targeted delivery of small‐molecule drugs via covalent attachments to monoclonal antibodies has proved successful in clinic. For this purpose, full‐length antibodies are mainly used as drug‐carrying vehicles. Despite their flexible conjugation sites and versatile biological activities, intact immunoglobulins with conjugated drugs, which feature relatively large molecular weights, tend to have restricted tissue distribution and penetration and low fractions of payloads. Linking small‐molecule therapeutics to ot… Show more
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