Synthesis of Schiff base Metal Complexes with Motivating Scavenging Potential Studies

Al-Azawi, Khalida F.; AL-Duhaidahawi, Dunya; Al-Amiery, Ahmed A.; Kadhum, Abdul Amir Hassan

doi:10.5530/fra.2019.1.1

Cited by 9 publications

(8 citation statements)

References 21 publications

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“…UV spectra of derived ligand in Dimethylformamide exhibits band assigned to π-π* transitions of aromatic ring in ligand and imino group at 340 nm. Another extra band is noted at 364 nm and is dependable for n-π* transitions 18 . The Cu(C30H21N7O4Cl2) complex gives bands at 505 and 604 nm due to 2 B1g→ 2 E1g and 2 B1g→ 2 A1g transitions.…”

Section: Magnetic Moment and Electronic Spectralmentioning

confidence: 94%

Synthesis and Biological Studies of Schiff Base Metal(II) Complexes Derived from Isatin

Sujeshwari¹,

Akila

Maheswaran³

2022

Int J Life Sci Pharm Res

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Potentially bioactive Schiff base metal complex is a kind of attractive reagents due to specific activities of pharmacology and physiology. Medical inorganic chemistry has exploited metal ions' unique properties to design new drugs. In this study a novel Cu(II), Ni(II), Mn(II) and Co(II) Schiff base complexes have been from p - nitroaniline, isatin and 2, 2′ bipyridyl. The elemental analyses of the complexes are confined to the stoichiometry of the type L1L2M [M = Cu(II), Ni(II), Mn(II) and Co(II)], respectively, where L is Schiff base ligand in the ratio of 1:1:1. Structures have been proposed from elemental analyses, IR, UV, 1H NMR, ESR spectral data and magnetic studies. The measured low molar conductance values in DMF indicate that the complexes are nonelectrolytes. The IR data tells us the association of C=N nitrogen atom in co - ordination to the metal ion. The UV spectral studies and magnetic measurements suggested the octahedral geometry around metal ion under investigation. The EPR spectral data shows additional proof for the octahedral geometry. In addition, the antioxidative activity was also determined. The ligand's antioxidative activity and its complexes demonstrate that, compared to the ligand, the complexes exhibit higher scavenging activity. The antibacterial activity of these compounds was studied in vitro by the disc diffusion assay against two Gram-positive bacteria like Staphylococcus aureus, Bacillus subtilis and two Gram-negative bacteria like Escherichia coli and Klebsilla pneumonia. The complexes show significant growth inhibitory activity than ligands.

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Section: Magnetic Moment and Electronic Spectralmentioning

confidence: 94%

Synthesis and Biological Studies of Schiff Base Metal(II) Complexes Derived from Isatin

Sujeshwari¹,

Akila

Maheswaran³

2022

Int J Life Sci Pharm Res

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“…General procedure for prepare of imine compounds [5][6][7][8]: Imine compounds are preparation by mixing 0.01moleof amine and 0.02 mole ofaldehydepresence trace of glacial acetic acid in 25 mL abs. ethanol, the reaction completed for 4hours, the purity of the Imine compounds were monitored with Thin Lear Chromatography.…”

Section: Methodsmentioning

confidence: 99%

Preparation of some metallic complexes from selected organic ligands and characterization it spectrophotometry as a model of a ligand scavenger to metals in health applications

Mahmood¹,

Awad²,

Muslim³

2020

ATMPH

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The research included prepare imines from the primary aromatic amine 4.4-dithioaniline with aromatic aldehydes. The imine compounds (R 1 -R 6 ) were characterized spectroscopically by UV / Vis, FT-IR, 1 H-NMR and the melting point was taken for these compounds, when the reaction of the imine compounds with the metal ions Pd(II) leads to the formation of palladium complexes (R 7 -R 12 ). The complexes were characterized spectroscopically by UV / Vis, FT-IR, mass spectrometry, C.H.N.S. and molar conductivity, which proved that non-electrolyte palladium complexes. Magnetic measurements have been taken that have an important role in knowing the geometry shape of the complexes, Palladium complexes are square planar.

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“…The three bands were shown for Ni (C 30 H 21 N 7 O 4 Cl 2 ) complexin the range of 446, 578 and 625 nm, responsible to 3 A 2g (F) → 3 T 1 g(F), 3 A 2g (F) → 3 T 2 g(F) and 3 A 2g (F) → INCT, LMCT 3 A 2g (F) → 3 T 2 g(F), 3 A 2g (F) → 3 T 1 g(F) 3 A 2g (F) → compound gives an idea of the exacted geometry and the nature of ligating sites around the central metal ion 11 .…”

Section: Synthesis Of (1-methylmentioning

confidence: 99%

Untitled

2023

IJPSR

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Potentially bioactive tetradentate novel Schiff base ligand and its mononuclear metal (II) complexes have been synthesized by the condensation method of p -nitroaniline, isatin, and 2, 2′ bipyridyl molecules in the ratio of 1:1:1. The ligand and its reported complexes exactly categorized by diverse physicochemical techniques that include elemental analysis, conductance measurements, IR, electronic spectra studies, 1 H NMR spectroscopy, and EPR studies. Derived complexes are exactly non-electrolyte in nature in Dimethylformamide solution because of their lower conductance values. The IR data tells us the association of C=N nitrogen atom in coordination to the metal ion. Electronical studies and magnetic measurements suggested the octahedral geometry around metal ion under investigation. The EPR spectral data shows additional proof for the octahedral geometry. The nucleolytic cleavage of the reported compounds was checked upon pUC18 DNA by gel -electrophoresis method. In this study, anti-oxidant and anti-microbial activities have also been evidently studied. The compounds show exact growth inhibitory activity over bacteria such as S. aureus, E. coli, B. subtilis and K, pneumonia than derived free ligands. INTRODUCTION:The success of developing cisplatin as an effectual anticancer agent has drawn the notice of numerous bio-inorganic chemists en route to preparing the numerous transition metal complexes with enhanced anticancer efficacy 1 . Even though there are several biological issues in anticancer cells, which includes Ribonucleic acid, protein or enzyme and is admitted universally that Deoxy Ribonucleic acid is the prime acheivement for several anticancer drugs.

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Synthesis of Schiff base Metal Complexes with Motivating Scavenging Potential Studies

Cited by 9 publications

References 21 publications

Synthesis and Biological Studies of Schiff Base Metal(II) Complexes Derived from Isatin

Synthesis and Biological Studies of Schiff Base Metal(II) Complexes Derived from Isatin

Preparation of some metallic complexes from selected organic ligands and characterization it spectrophotometry as a model of a ligand scavenger to metals in health applications

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