“…1,2 To date, the number of fungicides that have ambimobility activity (both phloem mobile and xylem mobile) in plants is very limited, exemplified by fungicides such as metalaxyl, 3 or phosethyl-Al. 4 Successful attempts have been made to achieve this goal by changing the physicochemical properties of molecular structures 1,5 or introducing a small molecule which is endogenous and can bi-directionally transport in plant, 6 such as an amino acid, [7][8][9][10][11] or a sugar [12][13][14] onto the non-phloem mobile agrochemicals. For example, to fit the Kleier prediction model widely employed to predict whether xenobiotics are capable of phloem transport ability based on their physical and chemical properties (log K ow and pKa, respectively), an acidic derivative of the fungicide fenpiclonil, N-carboxymethyl-3cyano-4-(2,3-dichlorophenyl)pyrrole, showing moderate phloem mobility was designed and synthesized, and it was found to exhibit high phloem mobility using the castor bean system.…”