Synthesis of RNA-Amphiphiles via Atom Transfer Radical Polymerization in the Organic Phase

Jeong, Jaepil; Szczepaniak, Grzegorz; Das, Sauvik; Matyjaszewski, Krzysztof

doi:10.1021/prechem.3c00042

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…The methacrylic RNA crosslinker was then polymerized by photo-ATRP − or photoinduced electron/energy transfer RAFT polymerization (PET-RAFT) − in PBS under green light irradiation using eosin Y (EYH 2 ) and oligo(ethylene oxide) methyl ether methacrylate (OEOMA 500 , M n = 500) as the photocatalyst and the model comonomer, respectively (Figure A). A notable photobleaching of eosin Y was observed after 30 min of PET-RAFT polymerization (Figure B), which was consistent with previous findings .…”

Section: Results and Discussionmentioning

confidence: 99%

Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

Jeong,

An,

et al. 2023

ACS Nano

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Nucleic acids extracted from biomass have emerged as sustainable and environmentally friendly building blocks for the fabrication of multifunctional materials. Until recently, the fabrication of biomass nucleic acid-based structures has been facilitated through simple crosslinking of biomass nucleic acids, which limits the possibility of material properties engineering. This study presents an approach to convert biomass RNA into an acrylic crosslinker through acyl imidazole chemistry. The number of acrylic moieties on RNA was engineered by varying the acylation conditions. The resulting RNA crosslinker can undergo radical copolymerization with various acrylic monomers, thereby offering a versatile route for creating materials with tunable properties (e.g., stiffness and hydrophobic characteristics). Further, reversible-deactivation radical polymerization methods, such as atom transfer radical polymerization (ATRP) and reversible addition–fragmentation chain transfer (RAFT), were also explored as additional approaches to engineer the hydrogel properties. The study also demonstrated the metallization of the biomass RNA-based material, thereby offering potential applications in enhancing electrical conductivity. Overall, this research expands the opportunities in biomass-based biomaterial fabrication, which allows tailored properties for diverse applications.

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Section: Results and Discussionmentioning

confidence: 99%

Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

Jeong,

An,

et al. 2023

ACS Nano

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“…The versatility of this system was further demonstrated through successful polymerization with multiscale nucleic acid scaffolds, highlighting its potential for applications in materials science and biotechnology. By leveraging programmable self-assembly (e.g., toehold mediated strand displacement) and nucleic acid amplification techniques (e.g., polymerase chain reaction and rolling circle amplification), − we anticipate that the NuABD -based photocatalytic ATRP platform would open new opportunities such as stimuli-responsive polymerization, , nanofabrication, , and nucleic acid–polymer biohybrids. ,,, …”

Section: Discussionmentioning

confidence: 99%

Nucleic Acid-Binding Dyes as Versatile Photocatalysts for Atom-Transfer Radical Polymerization

Jeong,

Hu,

Yin

et al. 2024

J. Am. Chem. Soc.

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Nucleic acid-binding dyes (NuABDs) are fluorogenic probes that light up after binding to nucleic acids. Taking advantage of their fluorogenicity, NuABDs have been widely utilized in the fields of nanotechnology and biotechnology for diagnostic and analytical applications. We demonstrate the potential of NuABDs together with an appropriate nucleic acid scaffold as an intriguing photocatalyst for precisely controlled atom-transfer radical polymerization (ATRP). Additionally, we systematically investigated the thermodynamic and electrochemical properties of the dyes, providing insights into the mechanism that drives the photopolymerization. The versatility of the NuABD-based platform was also demonstrated through successful polymerizations using several NuABDs in conjunction with diverse nucleic acid scaffolds, such as G-quadruplex DNA or DNA nanoflowers. This study not only extends the horizons of controlled photopolymerization but also broadens opportunities for nucleic acid-based materials and technologies, including nucleic acid−polymer biohybrids and stimuli-responsive ATRP platforms.

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Current status and outlook for ATRP

Matyjaszewski

2024

European Polymer Journal

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Synthesis of RNA-Amphiphiles via Atom Transfer Radical Polymerization in the Organic Phase

Cited by 3 publications

References 35 publications

Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

Nucleic Acid-Binding Dyes as Versatile Photocatalysts for Atom-Transfer Radical Polymerization

Current status and outlook for ATRP

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