Synthesis of radioiodinated thymoquinone glucuronide conjugated magnetic nanoparticle (&lt;sup&gt;125&lt;/sup&gt;i-tqg-fe&lt;sub&gt;3&lt;/sub&gt;o&lt;sub&gt;4&lt;/sub&gt;) and its cytotoxicity and in vitro affinity

Ince, İ̇skender; Müftüler, Zümrüt Biber; Medine, E. Ilker; Guldu, Ozge Kozgus; Tekin, Volkan; Aktar, Selin; Göker, Erdem; Ünak, Perihan

doi:10.23893/1307-2080.aps.05608

Cited by 1 publication

(2 citation statements)

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“…Cancer cell line A549 exposed to 10 drugs respond with the same IC-50 TET1 as reported by different papers. 60,92,94,96 Cancer cell line MDA-MB-231 exposed to 9 different drugs respond with the same TET1 as reported by 8 different papers. 54,70,72,95,102,105,106 and 120 Cancer cell line MCF-7 has a mixed response to drugs but responds with IC-50 TET1 to 12 drugs as reported by 9 papers.…”

Section: Typementioning

confidence: 54%

“…9 Third, cell density expressed as cellular confluence degree: 70% 3 and 80%. 8 In addition, the microplates 'size used in these studies have between 96, 384 and 1536 wells with a reaction volume (which contain cells, media, serum and drugs) respectively 100μl, 20μl and 5μl. The combination of these experimental conditions cannot guarantee for one cancer cell line to grow and respond to the same drug the same way in different studies.…”

Section: Introductionmentioning

confidence: 99%

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The IC-50-time evolution is a new model to improve drug responses consistency of large scale studies

Alileche

2022

F1000Res

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Large-scale studies combining hundreds of cancer cell lines and many cancer drugs, with their promises and challenges, represent a new development in the in vitro screening of cancer drugs. However, drugs sensitivity results of the same cancer cell lines exposed to the same cancer drugs generated different IC50s by these studies as noticed by Haibe-Kains B et al (1). These inconsistencies are due to many factors: the experimental conditions and the use of the Four Parameter Logistic (4PL) regression model to analyze drugs sensitivity results. A new model based on the Levasseur LM et al model, the Gompertzian growth model of in vitro monolayer culture, and the IC-50 time course evolution is more appropriate to improve the accuracy of these large scale studies.

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Section: Typementioning

confidence: 54%