Synthesis of pyrrolo[2,3-d]pyrimidines (microreview)

Sajadikhah, Seyed Sajad; Zare, Abdolkarim

doi:10.1007/s10593-019-02595-2

Cited by 6 publications

(1 citation statement)

References 12 publications

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“…[5][6][7][8] Great effort has been directed toward the synthesis of pyrrolo [2,3-d]pyrimidines and their derivatives, due to their immense potential in terms of pharmacological activity against various diseases. [9][10][11][12][13] Studies on pyrrolo [2,3-d]pyrimidine synthesis have mainly used conventional thermal heating. However, thermal synthetic reactions require many synthetic steps to introduce diverse substituents to pyrrolo [2,3-d]pyrimidines.…”

Section: Introductionmentioning

confidence: 99%

A microwave‐assisted synthetic approach to analyzing disubstituted pyrrolo[2,3‐d]pyrimidine diversity via ligand‐free Cu‐catalyzed N‐arylation

Hong

Park

Byeon

et al. 2021

Bulletin Korean Chem Soc

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Facile introduction of diverse substituents to 2-or 4-chloro-7H-pyrrolo [2,3-d] pyrimidines was examined with microwave-assisted nucleophilic substitution and Cu-catalyzed N-arylation. Microwave-assisted Cu-catalyzed N-arylation of pyrrolo[2,3-d]pyrimidines with various nucleophiles proceeded very well with diverse heteroaryl halides. Sequential microwave-assisted substitution provided good to excellent yields of 2,7-or 4,7-disubstituted pyrrolo[2,3-d]pyrimidines, with short reaction times and energy savings compared with conventional thermal heating. The diverse pyrrolo[2,3-d]pyrimidine derivatives are useful for screening drug candidates for various diseases.

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