Synthesis of Pyridine-Based Imine Compounds and Molecular Docking Studies Against Dopamine D2 Receptors

Abstract

In this study, new pyridine-based imine compounds were synthesized and it was investigated whether these compounds inhibit the D2 Dopamine receptor (6CM4) in silico. The structures of the compounds synthesized using the microwave method were determined by 1H-NMR, 13C-NMR and elemental analysis techniques. Later, Molecular Docking (MD) studies were used to determine the effects of synthesized compounds and risperidone on the D2 receptor. Risperidone drug and synthesized molecules (8-10) strongly interacted with D2 Dopamine Receptor /PDB: 6MC4 with energies of -10.34, -6.79, -6.95, -7.07 kcal/mol. The order of activity detected in the synthesized compounds is 10, 9, and 8 when the results are examined.