Synthesis of pyridazinedione derivatives starting from anhydrides of 2,3-pyridine- and 2,3-quinolinedicarboxylic acids

Abstract

A method was developed of preparation of heterocyclic compounds with pyridopyridazinoisoquinalinedione and isoquinopyridazinoquinalinedione structures formed regioselectively by intramolecular cyclization of phosphorus ylides containing pyridopyridazinedione and pyridazinoquinolinedione fragments.

Ionic liquid-catalyzed and microwave-assisted syntheses of pyrrolizine- and indolizinedione derivatives

“…We previously showed [9][10][11][12][13] that keto-stabilized sulfonium and phosphonium ylides derived from N-substituted α-and β-amino acids undergo intramolecular cyclization. We synthesized compounds having pyrrolizine and indolizine fragments from phosphorus ylides I and II which were obtained by acylation of simple alkylidenephosphoranes with N-phthaloyl amino acids III and IV (transylidation), which allowed us to considerably reduce the number of DOI: 10.1134 steps as compared to salt and carbene procedures used previously.…”