Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent

Zhang, Ying; Liu, Jingying; Ma, Song; Zhang, Yajing; Zhao, Xiang; Zhang, Xiangdong; Zhang, Zhidong

doi:10.1007/s10856-009-3881-3

Cited by 85 publications

(54 citation statements)

References 21 publications

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“…Superparamagnetic NPs are not soluble in aqueous medium and to increase their stability, these particles are coated with carboxylates, inorganic materials, and polymers [24]. For example, carboxymethyl dextran [32], polyvinylpyrrolidone [33], dextran [34], and polyvinyl alcohol [35] coatings have been used to the synthesis of iron oxide NPs. To increase the biodegradability, IFNPs were coated with a new coating material of dextrin.…”

Section: Physical and Magnetic Characterizationsmentioning

confidence: 99%

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

et al. 2015

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Iron oxide nanoparticles, such as ferrites, offer some attractive possibilities in biomedicine, especially in MRI applications. The objective of this study is to investigate the effectiveness of dextrin-coated zinc-iron ferrite nanoparticles (IFNPs) as an MRI contrast agent in in vivo and in vitro media. IFNPs were synthesized by an aqueous precipitation method in the presence of dextrin. An agarose phantom with different concentrations of dextrin-coated IFNPs was performed on a 1.5-T MRI. For in vivo MRI studies, implanted melanoma tumors in mice were immediately scanned after intra-tumoral injection of dextrincoated IFNPs. Microscopic studies showed that the average diameter of dextrin-coated IFNPs was 12 ± 2.4 nm and the saturation magnetization for IFNPs was 31.5 emu g -1 ; r 1 and r 2 relaxivities of these ultrasmall superparamagnetic IFNPs in agarose phantom were obtained as 0.99 and 17.4 mmol L -1 s -1 , respectively. The relaxivity measurements revealed that the dextrin-coated IFNPs can serve as a negative contrast agent. In vivo MRI showed that the dextrin-coated IFNPs can be used for tumor detection. The dextrin-coated IFNPs were suggested to be applied for lymph node and targeted imaging.

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Section: Physical and Magnetic Characterizationsmentioning

confidence: 99%

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

et al. 2015

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“…Fe 3 O 4 nanocrystal powder has excellent magnetic properties and is nontoxic, highly stabile, and promising for biological applications such as immobilization of enzymes [1][2][3] and proteins [4][5][6], magnetic separation of cells [7][8][9], and synthesis of a nucleotide [10]. Superparamagnetic Fe 3 O 4 nanoparticles are important for biomedical applications such as drug delivery [11][12][13][14], magnetic resonance imaging [15][16][17][18], hyperthermia [19][20][21], and immunoassays [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Direct transformation from goethite to magnetite nanoparticles by mechanochemical reduction

Iwasaki

Sato

Kosaka

et al. 2011

Journal of Alloys and Compounds

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“…Ironoxide nanoparticles, for instance, improved the resolution of images taken from ultrasound and MRI due to a better contrast ratio [1] and also were used for enzyme immobilization [2] or pathogen detection [3]. Polymer-based nanoparticles associated with drugs were designed to enhance a pharmacokinetic value, which determines the strength of drug delivery system [4].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle popsicle: Transdermal delivery of nanoparticles using polymeric microneedle array

Lee

Choi

2011

Korean J. Chem. Eng.

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A number of nanoparticles are currently applied for medical or medicinal research fields through conjugating with drugs or bio-molecules such as DNA, RNA, and peptides. There are three distinct ways to deliver nanoparticles into animal and human bodies: injection, feeding, and transdermal administration. We fabricated a polymeric microneedle array carrying nanoparticles on the end-tip of needles for an efficient delivery of functional nanoparticles through the skin. The polymeric microneedles with a length ranging from 600 to 1,000 µm were casted out using laser-printed PDMS (polydimethylsiloxane) molds where the 50 nm silica or polystyrene nanoparticles had been filled by centrifugation. When the microneedle array was applied to the porcine cadaver skin, nanoparticles were quickly and stably dispersed in the hypodermis. Microneedle array conjugated with nanoparticles has a potential for an alternative method to deliver cosmetic or pharmaceutical materials into human skin locally without professional procedures.

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Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent

Cited by 85 publications

References 21 publications

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

Direct transformation from goethite to magnetite nanoparticles by mechanochemical reduction

Nanoparticle popsicle: Transdermal delivery of nanoparticles using polymeric microneedle array

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