Synthesis of Potentially Biologically Active Fused Polyheterocycles Containing a Pyrimidine Unit

Soliman, M. R.; El-Ahwany, M. F.; Sherif, Mohamed H.; Assy, M. G.

doi:10.1134/s1070428019120182

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Triazole, tetrazole, oxazole, imidazole and pyrazole are receiving much more attention due to their potential biological activities. A lot of fused heterocyclic ring owning pyrimidinepyrazole 4 , benzoxazole 5 , benzimidazole, pyrimidotriazipine 6 , have been described as e cient pharmacophores. Among the overhead, pyrimidine based fused pharmacophore 7,8,9 plays a vital role for numerous biological activities such as analgesic 10 , anticonvulsant 11 , antiparkinsonian 12 , Anti bacterial 13,14 , anti-microbial 15 .…”

Section: Introductionmentioning

confidence: 99%

A Facile Environ-friendly One-pot Water-promoted Synthesis of Bis 1,2,3-triazole Linked Bis 2 - Aminopyrimidine Hybrids

Maheswari

Ponnuswamy

2023

Preprint

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Nitrogen-containing organic compounds play very vital roles in the research areas of organic chemistry, medicinal chemistry, and pesticidal chemistry. In recent times, the chemistry of heterocyclic triazole derivatives and 2-amino pyrimidine derivatives has attracted much attention owing to their versatile pharmacological properties1,2,3. Triazole, tetrazole, oxazole, imidazole and pyrazole are receiving much more attention due to their potential biological activities. A lot of fused heterocyclic ring owning pyrimidinepyrazole4, benzoxazole5, benzimidazole, pyrimidotriazipine6, have been described as efficient pharmacophores. Among the overhead, pyrimidine based fused pharmacophore7,8,9 plays a vital role for numerous biological activities such as analgesic10, anticonvulsant11, antiparkinsonian12, Anti bacterial13,14, anti-microbial15. They also serve as potential chemotherapeutic agents for various diseases16,17. Thus the synthesis of these type of pharmacophore is crucial now a days to our humanity.

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